Daytime administration of melatonin has better protective effects on bone loss in ovariectomized rats

• Published in: Journal of orthopaedic surgery and research Vol. 18; no. 1; pp. 234 - 13
• Main Authors: Li, Tian-lin, Liu, He-dong, Ren, Mao-xian, Zhou, Zhi, Jiang, Wen-kai, Yang, Min
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.03.2023; BioMed Central; BMC
• Subjects: Abdomen; Animals; Antigens; Apoptosis; Biomarkers; Biomechanics; Bone biomechanics; Bone Density; Bone Diseases, Metabolic; Bone growth; Bone loss; Bone mass; Bone resorption; Bone turnover; Bones; Cancellous bone; Cell viability; Cholecystokinin; Computed tomography; Daytime; Denosumab; Density; Estrogen deficiency; Experiments; Female; Femur; Histology; Humans; Injection; Kinases; Medical research; Melatonin; Melatonin - pharmacology; Melatonin - therapeutic use; Metabolism; Molecular biology; Nighttime; Oophorectomy; Orthopedics; Osteogenesis; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - prevention & control; Ovariectomy; Ovariectomy - adverse effects; Ovaries; Patient compliance; Physiological aspects; Proteins; Rats; Reactive Oxygen Species; Software; Surgery; China; Beijing China; United States > US; Osteoporosis; Melatonin; Bone mass; Bone loss; Estrogen deficiency

To explore the difference in the protective effects of intraperitoneal injection of exogenous melatonin of daytime or nighttime on bone loss in ovariectomized (OVX) rats. After bilateral ovariectomy and sham surgery, 40 rats were randomly divided into four groups: sham operation group (Sham), ovarie...