M1 macrophage-derived exosomes inhibit cardiomyocyte proliferation through delivering miR-155

• Published in: BMC cardiovascular disorders Vol. 24; no. 1; pp. 365 - 11
• Main Authors: He, Xiaoqing, Liu, Shan, Zhang, Zhanyu, Liu, Qirui, Dong, Juan, Lin, Zhifeng, Chen, Junhao, Li, Lihuan, Liu, Weihua, Liu, Shaojun, Liu, Shiming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.07.2024; BioMed Central; BMC
• Subjects: Analysis; Animals; Antibodies; Cardiomyocyte proliferation; Cardiomyocytes; Care and treatment; Cell Proliferation - drug effects; Cells, Cultured; Coculture Techniques; Diagnosis; Disease Models, Animal; Exosomes; Exosomes - genetics; Exosomes - metabolism; Exosomes - transplantation; Granulocyte-macrophage colony-stimulating factor; Heart; Heart attack; Heart cells; Heart failure; Immunoblotting; Immunofluorescence; Interleukin 6; Interleukin 6 receptors; Interleukin-6 - metabolism; Interleukins; Janus kinase; Janus kinase 2; Janus Kinase 2 - metabolism; Laboratory animals; M1 macrophage; Macrophages; Macrophages - metabolism; Male; Mice, Inbred C57BL; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Mir-155; miRNA; Myocardial infarction; Myocardial Infarction - genetics; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Penicillin; Phosphorylation; Rats, Sprague-Dawley; Receptors, Interleukin-6 - genetics; Receptors, Interleukin-6 - metabolism; Regeneration; Reporter gene; Risk factors; Signal Transduction; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; γ-Interferon; China; Cardiomyocyte proliferation; Myocardial infarction; Mir-155; Exosomes; M1 macrophage

M1 macrophages are closely associated with cardiac injury after myocardial infarction (MI). Increasing evidence shows that exosomes play a key role in pathophysiological regulation after MI, but the role of M1 macrophage-derived exosomes (M1-Exos) in myocardial regeneration remains unclear. In this...