Predicting gestational diabetes mellitus risk at 11–13 weeks’ gestation: the role of extrachromosomal circular DNA

• Published in: Cardiovascular diabetology Vol. 23; no. 1; pp. 289 - 13
• Main Authors: Wang, Jin, Huang, Pengyu, Hou, Fei, Hao, Dongdong, Li, Wushan, Jin, Hua
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.08.2024; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; Adult; AKT protein; Bioinformatics; Biomarkers; Biomarkers - blood; Case-Control Studies; Cell-Free Nucleic Acids - blood; Cell-Free Nucleic Acids - genetics; Child care; Circular DNA; Diabetes mellitus; Diabetes, Gestational - blood; Diabetes, Gestational - diagnosis; Diabetes, Gestational - genetics; DNA methylation; DNA, Circular - blood; DNA, Circular - genetics; Early Diagnosis; Extrachromosomal circular DNA; Female; Gestation; Gestational Age; Gestational diabetes; Gestational diabetes mellitus; Glucose; Humans; Insulin resistance; MAP kinase; MicroRNAs; Normal distribution; Plasma; Polymerase chain reaction; Predictive biomarker; Predictive Value of Tests; Pregnancy; Pregnancy complications; Pregnancy Trimester, First - blood; Rap1 protein; Reproducibility of Results; Risk Assessment; Risk Factors; Software; Womens health; United States > US; China; Germany; Gestational diabetes mellitus; Extrachromosomal circular DNA; Predictive biomarker

Gestational diabetes mellitus (GDM) significantly impacts maternal and infant health both immediately and over the long term, yet effective early diagnostic biomarkers are currently lacking. Thus, it is essential to identify early diagnostic biomarkers for GDM risk screening. Extrachromosomal circul...