Clinical, ultrastructural immunohistochemical and DNA content analysis of lymphomas having features of interdigitating reticulum cells

• Published in: Cancer Vol. 61; no. 8; pp. 1594 - 1601
• Main Authors: Rabkin, Michael S., Kjeldsberg, Carl R., Hammond, M. Elizabeth, Wittwer, Carl T., Nathwani, Bharat
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 15.04.1988; Wiley-Liss
• Subjects: Adolescent; Aneuploidy; Antigens, Neoplasm - analysis; Biological and medical sciences; Dendritic Cells - analysis; Dendritic Cells - pathology; DNA, Neoplasm - analysis; Female; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Large B-Cell, Diffuse - analysis; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, Non-Hodgkin - analysis; Lymphoma, Non-Hodgkin - pathology; Male; Medical sciences; Neoplasm Proteins - analysis; Human; Immunohistochemistry; Pathology; Histiocyte; S 100 Protein; DNA; Nosology; Hemopathy; Non Hodgkin lymphoma; Electron microscopy; Reticular dendritic cell; Child

Interdigitating reticulum cells (IRC) are dendritic, nonphagocytic histiocytes found in thymus‐dependent areas of lymphoid tissues. We report two cases of large cell lymphoma having features of IRC in patients 13 and 17 years old. In each case the diagnosis was suggested by light and electron micros...