Clinical, ultrastructural immunohistochemical and DNA content analysis of lymphomas having features of interdigitating reticulum cells

Interdigitating reticulum cells (IRC) are dendritic, nonphagocytic histiocytes found in thymus‐dependent areas of lymphoid tissues. We report two cases of large cell lymphoma having features of IRC in patients 13 and 17 years old. In each case the diagnosis was suggested by light and electron micros...

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Bibliographic Details
Published inCancer Vol. 61; no. 8; pp. 1594 - 1601
Main Authors Rabkin, Michael S., Kjeldsberg, Carl R., Hammond, M. Elizabeth, Wittwer, Carl T., Nathwani, Bharat
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 15.04.1988
Wiley-Liss
Subjects
Adolescent
Aneuploidy
Antigens, Neoplasm - analysis
Biological and medical sciences
Dendritic Cells - analysis
Dendritic Cells - pathology
DNA, Neoplasm - analysis
Female
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Large B-Cell, Diffuse - analysis
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Non-Hodgkin - analysis
Lymphoma, Non-Hodgkin - pathology
Male
Medical sciences
Neoplasm Proteins - analysis
Human
Immunohistochemistry
Pathology
Histiocyte
S 100 Protein
DNA
Nosology
Hemopathy
Non Hodgkin lymphoma
Electron microscopy
Reticular dendritic cell
Child
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Summary:Interdigitating reticulum cells (IRC) are dendritic, nonphagocytic histiocytes found in thymus‐dependent areas of lymphoid tissues. We report two cases of large cell lymphoma having features of IRC in patients 13 and 17 years old. In each case the diagnosis was suggested by light and electron microscopic features, positive immunoperoxidase staining for S‐100 protein, and additional immunoperoxidase findings. Both patients presented with aggressive lymphomas and were treated with intensive combination chemotherapy. Each patient achieved a complete clinical remission, then rapidly relapsed and died with disseminated disease 3 and 9 months after presentation. Novel findings included strong staining of specimens with an antibody to epithelial membrane antigen, staining of one specimen with peanut agglutinin in the pattern previously described in normal IRC, and a DNA content analysis that showed aneuploid stem cell lines in both patients.
Bibliography:Recipient of financial support from the American Cancer Society.
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19880415)61:8<1594::AID-CNCR2820610817>3.0.CO;2-G