Effect of altered gastric emptying and gastrointestinal motility on metformin absorption

• Published in: British journal of clinical pharmacology Vol. 50; no. 4; pp. 325 - 332
• Main Authors: Marathe, Punit H., Wen, Yandong, Norton, Jean, Greene, Douglas S., Barbhaiya, Rashmi H., Wilding, Ian R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2000; Blackwell Science; Blackwell Science Inc
• Subjects: absorption; Adult; Biological and medical sciences; Cross-Over Studies; Dopamine Agonists - pharmacology; Drug Interaction; Drug Interactions; Female; gamma scintigraphy; Gastric Emptying - physiology; gastrointestinal motility; Gastrointestinal Motility - physiology; Hormones. Endocrine system; Humans; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - pharmacokinetics; Intestinal Absorption - physiology; Male; Medical sciences; metformin; Metformin - adverse effects; Metformin - pharmacokinetics; Metoclopramide - pharmacology; Muscarinic Antagonists - pharmacology; Pharmacology. Drug treatments; Propantheline - pharmacology; Human; Hypoglycemic agent; Biguanides; Motility; Healthy subject; Oral administration; Gastric emptying; Metformin; Gastrointestinal; Metabolism; Pharmacokinetics; Digestive transit

Aims The purpose of this in vivo human study was to assess the effect of altered gastric emptying and gastrointestinal motility on the absorption of metformin in healthy subjects. Methods An open‐label, three treatment, three period crossover study was conducted in 11 healthy volunteers. Each subjec...