A comparison of the residual effects of zaleplon and zolpidem following administration 5 to 2 h before awakening

• Published in: British journal of clinical pharmacology Vol. 48; no. 3; pp. 367 - 374
• Main Authors: DANJOU, P, PATY, I, FRUNCILLO, R, WORTHINGTON, P, UNRUH, M, CEVALLOS, W, MARTIN, P
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.1999; Blackwell Science; Blackwell Science Inc
• Subjects: Acetamides - administration & dosage; Acetamides - adverse effects; Adult; Biological and medical sciences; Double-Blind Method; Drug Administration Schedule; Female; Humans; hypnotic; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Hypnotics. Sedatives; Male; Medical sciences; Memory - drug effects; Neuropharmacology; Original; Pharmacology. Drug treatments; Psychology. Psychoanalysis. Psychiatry; Psychomotor Performance - drug effects; Psychopharmacology; Pyridines - administration & dosage; Pyridines - adverse effects; Pyrimidines - administration & dosage; Pyrimidines - adverse effects; residual effects; sedative; zaleplon; Zolpidem; Human; Pharmacokinetic pharmacodynamic relationship; Agonist; Healthy subject; Psychotropic; Memory; Gabaergic agonist; Single dose; Hypnotic; Cognition; Residual effect; Blood; Zaleplon; Blood plasma; Awakening; Reaction time; Zolpidem; Clinical trial; Response latency; Sedative; Pharmacokinetics; Gabaergic receptor A; Comparative study

Aims To compare the duration of the residual hypnotic and sedative effects of zaleplon with those of zolpidem and placebo following nocturnal administration at various times before morning awakening. Methods Zaleplon 10 mg, zolpidem 10 mg, or placebo was administered double‐blind to 36 healthy subje...