Feasibility of small animal cranial irradiation with the microRT system

• Published in: Medical physics (Lancaster) Vol. 35; no. 10; pp. 4735 - 4743
• Main Authors: Kiehl, Erich L., Stojadinovic, Strahinja, Malinowski, Kathleen T., Limbrick, David, Jost, Sarah C., Garbow, Joel R., Rubin, Joshua B., Deasy, Joseph O., Khullar, Divya, Izaguirre, Enrique W., Parikh, Parag J., Low, Daniel A., Hope, Andrew J.
• Format: Journal Article
• Language: English
• Published: United States American Association of Physicists in Medicine 01.10.2008
• Subjects: ANIMALS; biological effects of ionising particles; BIOLOGICAL RADIATION EFFECTS; biomedical equipment; BRAIN; Brain Neoplasms - radiotherapy; CAT SCANNING; CNS; Comparative animal models; Computed tomography; computerised tomography; Conformal radiation treatment; conformal radiotherapy; dose response; Dosimetry; Equipment Design; Equipment Failure Analysis; EXTERNAL IRRADIATION; Feasibility Studies; HEAD; IMAGE PROCESSING; image registration; INTERNAL IRRADIATION; IRIDIUM 192; medical image processing; Medical imaging; Medical treatment planning; Mice; Mice, Inbred C57BL; Mice, Nude; Miniaturization; neurophysiology; PLANNING; POSITIONING; RADIATION DOSES; radiation therapy; Radiation Therapy Physics; Radiation treatment; radioisotopes; RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; Radiotherapy, Conformal - instrumentation; Radiotherapy, Conformal - veterinary; Registration; SIDE EFFECTS; small-animal; SPATIAL DOSE DISTRIBUTIONS; Therapeutic applications, including brachytherapy; Tissues; Treatment planning; tumours; CNS; conformal radiotherapy; dose response; brain; small-animal

Purpose: To develop and validate methods for small-animal CNS radiotherapy using the microRT system. Materials and Methods: A custom head immobilizer was designed and built to integrate with a pre-existing microRT animal couch. The Delrin® couch-immobilizer assembly, compatible with multiple imaging...