Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa

• Published in: Molecular microbiology Vol. 65; no. 4; pp. 896 - 906
• Main Authors: Cugini, Carla, Calfee, M. Worth, Farrow, John M. III, Morales, Diana K, Pesci, Everett C, Hogan, Deborah A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.08.2007; Blackwell Publishing Ltd; Blackwell Science
• Subjects: Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Biological and medical sciences; Candida albicans; Candida albicans - drug effects; Candida albicans - metabolism; Electrophoretic Mobility Shift Assay; Escherichia coli; Escherichia coli - drug effects; Farnesol - chemistry; Farnesol - pharmacology; Fundamental and applied biological sciences. Psychology; Fungi; Gene Expression Regulation, Bacterial - drug effects; Genes; Microbiology; Miscellaneous; Molecular biology; Molecules; Promoter Regions, Genetic - genetics; Protein Binding - drug effects; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - growth & development; Pseudomonas aeruginosa - metabolism; Pyocyanine - biosynthesis; Quinolones - metabolism; Recombinant Fusion Proteins - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Transcription, Genetic - drug effects; Pseudomonadales; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa; Sesquiterpenes

Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, leads to decreased production of the Pseudomonas quinolone signal (PQS) and t...