Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa

Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, leads to decreased production of the Pseudomonas quinolone signal (PQS) and t...

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Published inMolecular microbiology Vol. 65; no. 4; pp. 896 - 906
Main Authors Cugini, Carla, Calfee, M. Worth, Farrow, John M. III, Morales, Diana K, Pesci, Everett C, Hogan, Deborah A
Format Journal Article
LanguageEnglish
Published Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.08.2007
Blackwell Publishing Ltd
Blackwell Science
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Abstract Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, leads to decreased production of the Pseudomonas quinolone signal (PQS) and the PQS-controlled virulence factor, pyocyanin. Within 15 min of farnesol addition, decreased transcript levels of pqsA, the first gene in the PQS biosynthetic operon, were observed. Transcript levels of pqsR (mvfR), which encodes the transcription factor that positively regulates pqsA, were unaffected. An Escherichia coli strain producing PqsR and containing the pqsA promoter fused to lacZ similarly showed that farnesol inhibited PQS-stimulated transcription. Electrophoretic mobility shift assays showed that, like PQS, farnesol stimulated PqsR binding to the pqsA promoter at a previously characterized LysR binding site, suggesting that farnesol promoted a non-productive interaction between PqsR and the pqsA promoter. Growth with C. albicans leads to decreased production of PQS and pyocyanin by P. aeruginosa, suggesting that the amount of farnesol produced by the fungus is sufficient to impact P. aeruginosa PQS signalling. Related isoprenoid compounds, but not other long-chain alcohols, also inhibited PQS production at micromolar concen-trations, suggesting that related compounds may participate in interspecies interactions with P. aeruginosa.
AbstractList Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, leads to decreased production of the Pseudomonas quinolone signal (PQS) and the PQS-controlled virulence factor, pyocyanin. Within 15 min of farnesol addition, decreased transcript levels of pqsA, the first gene in the PQS biosynthetic operon, were observed. Transcript levels of pqsR (mvfR), which encodes the transcription factor that positively regulates pqsA, were unaffected. An Escherichia coli strain producing PqsR and containing the pqsA promoter fused to lacZ similarly showed that farnesol inhibited PQS-stimulated transcription. Electrophoretic mobility shift assays showed that, like PQS, farnesol stimulated PqsR binding to the pqsA promoter at a previously characterized LysR binding site, suggesting that farnesol promoted a non-productive interaction between PqsR and the pqsA promoter. Growth with C. albicans leads to decreased production of PQS and pyocyanin by P. aeruginosa, suggesting that the amount of farnesol produced by the fungus is sufficient to impact P. aeruginosa PQS signalling. Related isoprenoid compounds, but not other long-chain alcohols, also inhibited PQS production at micromolar concen-trations, suggesting that related compounds may participate in interspecies interactions with P. aeruginosa.
Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans . Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa , an opportunistic human bacterial pathogen, leads to decreased production of the Pseudomonas quinolone signal (PQS) and the PQS‐controlled virulence factor, pyocyanin. Within 15 min of farnesol addition, decreased transcript levels of pqsA , the first gene in the PQS biosynthetic operon, were observed. Transcript levels of pqsR ( mvfR ), which encodes the transcription factor that positively regulates pqsA , were unaffected. An Escherichia coli strain producing PqsR and containing the pqsA promoter fused to lacZ similarly showed that farnesol inhibited PQS‐stimulated transcription. Electrophoretic mobility shift assays showed that, like PQS, farnesol stimulated PqsR binding to the pqsA promoter at a previously characterized LysR binding site, suggesting that farnesol promoted a non‐productive interaction between PqsR and the pqsA promoter. Growth with C. albicans leads to decreased production of PQS and pyocyanin by P. aeruginosa , suggesting that the amount of farnesol produced by the fungus is sufficient to impact P. aeruginosa PQS signalling. Related isoprenoid compounds, but not other long‐chain alcohols, also inhibited PQS production at micromolar concen‐trations, suggesting that related compounds may participate in interspecies interactions with P. aeruginosa .
Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, leads to decreased production of the Pseudomonas quinolone signal (PQS) and the PQS-controlled virulence factor, pyocyanin. Within 15 min of farnesol addition, decreased transcript levels of pqsA, the first gene in the PQS biosynthetic operon, were observed. Transcript levels of pqsR (mvfR), which encodes the transcription factor that positively regulates pqsA, were unaffected. An Escherichia coli strain producing PqsR and containing the pqsA promoter fused to lacZ similarly showed that farnesol inhibited PQS-stimulated transcription. Electrophoretic mobility shift assays showed that, like PQS, farnesol stimulated PqsR binding to the pqsA promoter at a previously characterized LysR binding site, suggesting that farnesol promoted a non-productive interaction between PqsR and the pqsA promoter. Growth with C. albicans leads to decreased production of PQS and pyocyanin by P. aeruginosa, suggesting that the amount of farnesol produced by the fungus is sufficient to impact P. aeruginosa PQS signalling. Related isoprenoid compounds, but not other long-chain alcohols, also inhibited PQS production at micromolar concen-trations, suggesting that related compounds may participate in interspecies interactions with P. aeruginosa. [PUBLICATION ABSTRACT]
Summary Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, leads to decreased production of the Pseudomonas quinolone signal (PQS) and the PQS‐controlled virulence factor, pyocyanin. Within 15 min of farnesol addition, decreased transcript levels of pqsA, the first gene in the PQS biosynthetic operon, were observed. Transcript levels of pqsR (mvfR), which encodes the transcription factor that positively regulates pqsA, were unaffected. An Escherichia coli strain producing PqsR and containing the pqsA promoter fused to lacZ similarly showed that farnesol inhibited PQS‐stimulated transcription. Electrophoretic mobility shift assays showed that, like PQS, farnesol stimulated PqsR binding to the pqsA promoter at a previously characterized LysR binding site, suggesting that farnesol promoted a non‐productive interaction between PqsR and the pqsA promoter. Growth with C. albicans leads to decreased production of PQS and pyocyanin by P. aeruginosa, suggesting that the amount of farnesol produced by the fungus is sufficient to impact P. aeruginosa PQS signalling. Related isoprenoid compounds, but not other long‐chain alcohols, also inhibited PQS production at micromolar concen‐trations, suggesting that related compounds may participate in interspecies interactions with P. aeruginosa.
Author Morales, Diana K
Cugini, Carla
Hogan, Deborah A
Farrow, John M. III
Calfee, M. Worth
Pesci, Everett C
Author_xml – sequence: 1
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– sequence: 2
  fullname: Calfee, M. Worth
– sequence: 3
  fullname: Farrow, John M. III
– sequence: 4
  fullname: Morales, Diana K
– sequence: 5
  fullname: Pesci, Everett C
– sequence: 6
  fullname: Hogan, Deborah A
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18972532$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/17640272$$D View this record in MEDLINE/PubMed
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Keywords Pseudomonadales
Bacteria
Pseudomonadaceae
Pseudomonas aeruginosa
Sesquiterpenes
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Snippet Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to cultures of...
Summary Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans. Here, we report that the addition of farnesol to...
Farnesol is a sesquiterpene produced by many organisms, including the fungus Candida albicans . Here, we report that the addition of farnesol to cultures of...
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SubjectTerms Bacteria
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Candida albicans
Candida albicans - drug effects
Candida albicans - metabolism
Electrophoretic Mobility Shift Assay
Escherichia coli
Escherichia coli - drug effects
Farnesol - chemistry
Farnesol - pharmacology
Fundamental and applied biological sciences. Psychology
Fungi
Gene Expression Regulation, Bacterial - drug effects
Genes
Microbiology
Miscellaneous
Molecular biology
Molecules
Promoter Regions, Genetic - genetics
Protein Binding - drug effects
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - growth & development
Pseudomonas aeruginosa - metabolism
Pyocyanine - biosynthesis
Quinolones - metabolism
Recombinant Fusion Proteins - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcription, Genetic - drug effects
Title Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2958.2007.05840.x
https://www.ncbi.nlm.nih.gov/pubmed/17640272
https://www.proquest.com/docview/196521785
https://search.proquest.com/docview/20845935
Volume 65
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