在线制备^11C-Triflate-CH3
采用在线装置将^11C-CH3I转化成^11C-Triflate-CH3,并利用两者间脂溶性的区别,用HPLC方法分析转化效率和放化纯度.该方法在线转化效率大于95%,转化效率与温度有关,与气流无关（20～80 mL/min）;^11C-Triflate-CH3标记受体类药物标记率明显高于^11C-CH3I;一次装入该转换装置的试剂平均使用次数超过120次....
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| Published in | Tong wei su Vol. 19; no. 2; pp. 124 - 128 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
北京师范大学,化学系,北京,100875%解放军总医院,核医学科,北京,100853%北京师范大学,化学系,北京,100875
2006
解放军总医院,核医学科,北京,100853 西北核技术研究所,陕西,西安,710024%北京师范大学,化学系,北京,100875 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-7512 |
| DOI | 10.3969/j.issn.1000-7512.2006.02.014 |
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| Abstract | 采用在线装置将^11C-CH3I转化成^11C-Triflate-CH3,并利用两者间脂溶性的区别,用HPLC方法分析转化效率和放化纯度.该方法在线转化效率大于95%,转化效率与温度有关,与气流无关（20～80 mL/min）;^11C-Triflate-CH3标记受体类药物标记率明显高于^11C-CH3I;一次装入该转换装置的试剂平均使用次数超过120次. |
|---|---|
| AbstractList | TL92; 采用在线装置将11C-CH3I转化成11C-Triflate-CH3,并利用两者间脂溶性的区别,用HPLC方法分析转化效率和放化纯度.该方法在线转化效率大于95%,转化效率与温度有关,与气流无关(20～80 mL/min);11C-Triflate-CH3标记受体类药物标记率明显高于11C-CH3I;一次装入该转换装置的试剂平均使用次数超过120次. 采用在线装置将^11C-CH3I转化成^11C-Triflate-CH3,并利用两者间脂溶性的区别,用HPLC方法分析转化效率和放化纯度.该方法在线转化效率大于95%,转化效率与温度有关,与气流无关（20～80 mL/min）;^11C-Triflate-CH3标记受体类药物标记率明显高于^11C-CH3I;一次装入该转换装置的试剂平均使用次数超过120次. |
| Author | 王武尚 刘伯里 田嘉禾 张锦明 |
| AuthorAffiliation | 解放军总医院,核医学科,北京,100853;北京师范大学,化学系,北京,100875%解放军总医院,核医学科,北京,100853%北京师范大学,化学系,北京,100875;西北核技术研究所,陕西,西安,710024%北京师范大学,化学系,北京,100875 |
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| Author_FL | WANG Wu-shang TIAN Jia-he LIU Bo-li ZHANG Jin-ming |
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| Publisher | 北京师范大学,化学系,北京,100875%解放军总医院,核医学科,北京,100853%北京师范大学,化学系,北京,100875 解放军总医院,核医学科,北京,100853 西北核技术研究所,陕西,西安,710024%北京师范大学,化学系,北京,100875 |
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| Snippet | 采用在线装置将^11C-CH3I转化成^11C-Triflate-CH3,并利用两者间脂溶性的区别,用HPLC方法分析转化效率和放化纯度.该方法在线转化效率大于95%,转化效率与温度有关,与气流无关（20～80... TL92; 采用在线装置将11C-CH3I转化成11C-Triflate-CH3,并利用两者间脂溶性的区别,用HPLC方法分析转化效率和放化纯度.该方法在线转化效率大于95%,转化效率与温度有关,与气流无关(20～80... |
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| SubjectTerms | 11C-三氟甲基磺酰甲烷 11C-碘代甲烷 甲基化 |
| Title | 在线制备^11C-Triflate-CH3 |
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