TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease

• Published in: Journal of translational medicine Vol. 20; no. 1; pp. 414 - 14
• Main Authors: Lu, Hui, Wu, Xunyao, Peng, Yu, Sun, Ruijie, Nie, Yuxue, Li, Jingna, Wang, Mu, Luo, Yaping, Peng, Linyi, Fei, Yunyun, Zhou, Jiaxin, Zhang, Wen, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.09.2022; BioMed Central; BMC
• Subjects: Animals; Antibodies; Apoptosis; Autoimmune diseases; B cell; B cells; Care and treatment; CD19 antigen; CD4 antigen; Cell Proliferation; Chemokines; Cytokines; Cytokines - metabolism; Disease; Experiments; Flow cytometry; Follicular helper cell; Health aspects; IgG4-related disease; Immunofluorescence; Immunoglobulin G; Immunoglobulin G4-Related Disease; Immunohistochemistry; Immunologic diseases; Inflammation; JAK-STAT; Laboratory animals; Lymphocytes; Lymphocytes B; Lymphocytes T; Mice; Ox40L protein; Pathogenesis; Proteins; Remission (Medicine); RNA; Signal transduction; Statistical analysis; T cells; T Follicular Helper Cells; Therapeutic applications; Therapeutic targets; Thymic Stromal Lymphopoietin; Thymus; China; United States > US; Follicular helper cell; B cell; IgG4-related disease; Thymic stromal lymphopoietin; JAK-STAT

To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD). Plasma TSLP levels were tested by Elisa, and its receptors were detected by flow cytometry. Expressions of TSLP and TSLPR in involved tissues were stained by immunohistochemistry and immunofluoresce...