Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy

• Published in: Arthritis research & therapy Vol. 23; no. 1; pp. 251 - 16
• Main Authors: Cao, Yanlin, Zhan, Yenan, Qiu, Sujun, Chen, Zhong, Gong, Kaiqin, Ni, Songjia, Duan, Yang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.09.2021; BioMed Central; BMC
• Subjects: ACSM5; Analysis; Arthritis; Care and treatment; Cell fibrosis; Coenzyme A Ligases; Collagen; DNA (Cytosine-5-)-Methyltransferase 1; DNA methylation; DNA Methylation - genetics; Epigenetics; Gene expression; Genetic aspects; Genome-wide DNA methylation; Genomes; Humans; Hypertrophy - genetics; Hypertrophy of ligamentum flavum; Ligaments; Ligamentum Flavum - metabolism; Lumbar Vertebrae; Older people; Polymorphism; Polymorphism, Single Nucleotide; Single-nucleotide polymorphism; Spinal diseases; Spinal Stenosis - genetics; Spinal Stenosis - metabolism; Vertebrae; China; ACSM5; Single-nucleotide polymorphism; Genome-wide DNA methylation; Hypertrophy of ligamentum flavum; Cell fibrosis

Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration disease (LDD) with typical symptoms of low back pain and limb numbness owing to an abnormal pressure on spinal nerves. Previous studies revealed HLF might be caused by fibrosis, inflammatory, and other bio-pathways. However, a gl...