TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension

• Published in: Respiratory research Vol. 22; no. 1; pp. 312 - 15
• Main Authors: Cao, Xiaopei, Fang, Xiaoyu, Guo, Mingzhou, Li, Xiaochen, He, Yuanzhou, Xie, Min, Xu, Yongjian, Liu, Xiansheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.12.2021; BioMed Central; BMC
• Subjects: Animals; Antibodies; Apoptosis; Biotechnology; Blood pressure; Care and treatment; Cell Communication; Cell culture; Cellular stress response; Development and progression; Diagnosis; Disease Models, Animal; Endoplasmic reticulum; Endoplasmic Reticulum Stress - genetics; Flow cytometry; Gene Expression Regulation; Genomes; Health aspects; Health services; Heart; Homology; Hypertension; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - genetics; Hypertension, Pulmonary - metabolism; Hypoxia; Hypoxia - complications; Hypoxia - genetics; Hypoxia - metabolism; Laboratory animals; Lung diseases; Lungs; Male; MAP kinase; MAP Kinase Signaling System - genetics; MAPK; Microenvironments; Mitogen-activated protein kinases; Muscles; PASMCs; Pathogenesis; Patients; Protein Serine-Threonine Kinases - antagonists & inhibitors; Protein Serine-Threonine Kinases - biosynthesis; Protein Serine-Threonine Kinases - genetics; Proteins; Pulmonary arteries; Pulmonary artery; Pulmonary Artery - pathology; Pulmonary Artery - physiopathology; Pulmonary hypertension; Rats; Rats, Sprague-Dawley; Regulatory mechanisms (biology); Signal Transduction; Signaling; Smooth muscle; Systolic pressure; Thapsigargin; TRB3; Up-Regulation; Vascular Remodeling - genetics; Ventricle; China; United States > US; Japan; PH; TRB3; Hypoxia; MAPK; PASMCs

Hypoxic pulmonary hypertension (PH) is a refractory pulmonary vascular remodeling disease, and the efficiency of current PH treatment strategies is unsatisfactory. Tribbles homolog 3 (TRB3), a member of the pseudokinase family, is upregulated in diverse types of cellular stresses and functions as ei...