Methylated polycyclic aromatic hydrocarbons from household coal use across the life course and risk of lung cancer in a large cohort of 42,420 subjects in Xuanwei, China

• Published in: Environment international Vol. 173; p. 107870
• Main Authors: Portengen, Lützen, Downward, George, Bassig, Bryan A., Blechter, Batel, Hu, Wei, Wong, Jason Y.Y., Ning, Bofu, Rahman, Mohammad L., Ji, Bu-Tian, Li, Jihua, Yang, Kaiyun, Hosgood, H. Dean, Silverman, Debra T., Rothman, Nathaniel, Huang, Yunchao, Vermeulen, Roel, Lan, Qing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2023; Elsevier
• Subjects: Adolescent; Adult; adulthood; air; Air Pollutants - adverse effects; Bayes Theorem; Bayesian theory; Carcinogens; Case-Control Studies; China; China - epidemiology; coal; Coal - adverse effects; Coal - analysis; confidence interval; environment; Female; hazard ratio; Humans; Indoor air pollution; Life Change Events; Lifecourse epidemiology; Lung cancer epidemiology; lung neoplasms; Lung Neoplasms - chemically induced; methylation; mortality; pollutants; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - adverse effects; Polycyclic Aromatic Hydrocarbons - analysis; regression analysis; Retrospective Studies; risk; Solid biomass fuel burning; China; Polycyclic aromatic hydrocarbons; Indoor air pollution; Lifecourse epidemiology; Lung cancer epidemiology; Solid biomass fuel burning

We previously showed that exposure to 5-methylchrysene (5MC) and other methylated polycyclic aromatic hydrocarbons (PAHs) best explains lung cancer risks in a case-control study among non-smoking women using smoky coal in China. Time-related factors (e.g., age at exposure) and non-linear relations w...