Plasma mitochondrial DNA levels are associated with acute lung injury and mortality in septic patients

• Published in: BMC pulmonary medicine Vol. 21; no. 1; pp. 66 - 9
• Main Authors: Mao, Jia-yu, Li, Dong-kai, Zhang, Hong-min, Wang, Xiao-ting, Liu, Da-wei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.02.2021; BioMed Central; BMC
• Subjects: Acute lung injury; Acute respiratory distress syndrome; Biomarkers; Complications and side effects; Critical care; Cytokines; Deoxyribonucleic acid; Development and progression; DNA; Health aspects; Infections; Inflammation; Interleukin 6; Interleukin 8; Laboratories; Lungs; Medical prognosis; Mitochondrial DNA; Mortality; Patient outcomes; Patients; Plasma; Plasma mtDNA level; Procalcitonin; Pulmonology; Risk factors; Sepsis; China; Biomarkers; Acute lung injury; Sepsis; Plasma mtDNA level

Mitochondrial DNA (mtDNA) is a critical activator of inflammation. Circulating mtDNA released causes lung injury in experimental models. We hypothesized that elevated plasma mtDNA levels are associated with acute lung injury (ALI) in septic patients. We enrolled 66 patients with sepsis admitted to t...