Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)

• Published in: Environmental health Vol. 22; no. 1; pp. 19 - 47
• Main Authors: Ehrlich, Veronika, Bil, Wieneke, Vandebriel, Rob, Granum, Berit, Luijten, Mirjam, Lindeman, Birgitte, Grandjean, Philippe, Kaiser, Andreas-Marius, Hauzenberger, Ingrid, Hartmann, Christina, Gundacker, Claudia, Uhl, Maria
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.02.2023; BioMed Central; BMC
• Subjects: Acids; Alkanesulfonic Acids; Animals; Antibodies; Biocompatibility; Bisphenol A; Calcium signalling; Chemicals; Child; Children; Drinking water; Environmental health; Environmental Pollutants; Environmental protection; Epidemiology; Fatty acids; Fluorocarbons - analysis; HBM4EU; Health aspects; Health risk assessment; Health risks; Humans; Immune function; Immune system; Immunosuppression; Immunotoxicity; In vivo methods and tests; Keywords; Modulation; Molecular mechanisms; NF-κB protein; Nuclear receptors; Nuclear safety; Oxidative Stress; Per- and polyfluoroalkyl substances; Perfluoroalkyl & polyfluoroalkyl substances; Perfluorooctane sulfonic acid; Perfluorooctanoic acid; Persistent organic pollutants; Physiological aspects; Public Health; Review; Risk Assessment; Side effects; Signal transduction; Signaling; Vaccination response; Austria; United States > US; Vaccination response; HBM4EU; Immune function; Per- and polyfluoroalkyl substances; Immunotoxicity; Molecular mechanisms

Per- and polyfluoroalkyl substances (PFAS) are of public health concern, because of their ubiquitous and extremely persistent occurrence, and depending on their structure, their bio-accumulative, mobile and toxic properties. Human health effects associated with exposure to PFAS include adverse effec...