Association of circulating proprotein convertase subtilisin/kexin type 9 levels and the risk of incident type 2 diabetes in subjects with prediabetes: a population-based cohort study

• Published in: Cardiovascular diabetology Vol. 19; no. 1; pp. 209 - 13
• Main Authors: Shi, Jie, Zhang, Weiwei, Niu, Yixin, Lin, Ning, Li, Xiaoyong, Zhang, Hongmei, Hu, Renming, Ning, Guang, Fan, Jiangao, Qin, Li, Su, Qing, Yang, Zhen
• Format: Journal Article
• Language: English
• Published: England BioMed Central 10.12.2020; BMC
• Subjects: Blood pressure; Body mass index; C-reactive protein; Cholesterol; Cohort analysis; Creatinine; Diabetes; Diabetes mellitus (non-insulin dependent); Disease; Enzyme-linked immunosorbent assay; Glucose; Homeostasis; Hospitals; Insulin; Insulin resistance; Kexin; Lipid metabolism; Lipids; Metabolism; Original Investigation; PCSK9; Plasma; Population studies; Population-based studies; Prediabetes; Proprotein convertases; Questionnaires; R&D; Receptor density; Research & development; Subtilisin; Triglycerides; Type 2 diabetes; γ-Glutamyltransferase; Minneapolis Minnesota; United States > US; China; Japan; Type 2 diabetes; Prediabetes; PCSK9
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-020-01185-3

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by targeting the low-density lipoprotein receptor. Recent studies have shown that circulating PCSK9 is associated with glucose homeostasis and insulin resistance. The aim of this study was to examine the associati...