Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)

• Published in: Journal of translational medicine Vol. 20; no. 1; pp. 138 - 11
• Main Authors: Haffke, Milan, Freitag, Helma, Rudolf, Gordon, Seifert, Martina, Doehner, Wolfram, Scherbakov, Nadja, Hanitsch, Leif, Wittke, Kirsten, Bauer, Sandra, Konietschke, Frank, Paul, Friedemann, Bellmann-Strobl, Judith, Kedor, Claudia, Scheibenbogen, Carmen, Sotzny, Franziska
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.03.2022; BioMed Central; BMC
• Subjects: ACE2; Angiopoietin; Angiotensin; Angiotensin-converting enzyme 2; Biological markers; Biomarkers; Blood pressure; Chronic fatigue syndrome; Coronaviruses; COVID-19; COVID-19 - complications; Endothelial Cells; Endothelial dysfunction; Endothelin 1; Endothelium; Enzymes; Fatigue; Fatigue Syndrome, Chronic; Health aspects; Heart rate; Humans; Hyperemia; Hypoglycemia; Infections; Interleukin 8; Intolerance; Long COVID; Myalgic encephalomyelitis/chronic fatigue syndrome; Patients; Peptidyl-dipeptidase A; Post-COVID syndrome; Reactive hyperaemia index; Risk factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Germany; Endothelial dysfunction; Myalgic encephalomyelitis/chronic fatigue syndrome; Reactive hyperaemia index; Post-COVID syndrome; Endothelin-1

Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of Post-COVID Syndrome (PCS), with a subset of patients fulfilling criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). As SARS-CoV-2 infects endothelial cells, causing endotheliitis a...