Study Protocol for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a pragmatic, registry-based, multi-center, double-blind, randomized controlled trial evaluating the effect of intravenous fluid therapy with Plasma-Lyte 148 versus 0.9% saline on delayed graft function in deceased donor kidney transplantation

• Published in: Current controlled trials in cardiovascular medicine Vol. 21; no. 1; pp. 428 - 19
• Main Authors: Collins, Michael G., Fahim, Magid A., Pascoe, Elaine M., Dansie, Kathryn B., Hawley, Carmel M., Clayton, Philip A., Howard, Kirsten, Johnson, David W., McArthur, Colin J., McConnochie, Rachael C., Mount, Peter F., Reidlinger, Donna, Robison, Laura, Varghese, Julie, Vergara, Liza A., Weinberg, Laurence, Chadban, Steven J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.05.2020; BioMed Central; BMC
• Subjects: Acidosis; Administration, Intravenous; Analysis; Australia; Balanced crystalloid; Chloride; Chlorides; Chronic kidney failure; Clinical trials; Clinical Trials, Phase III as Topic; Costs; Delayed graft function; Delayed Graft Function - epidemiology; Delayed Graft Function - etiology; Double-Blind Method; Double-blind studies; End-stage kidney disease; Fluid Therapy - methods; Fluids; Gluconates - pharmacology; Graft Survival; Grants; Health aspects; Health care costs; Hemodialysis; Hospitals; Humans; Hyperkalemia; Intravenous fluids; Intravenous therapy; Kidney diseases; Kidney transplantation; Kidney Transplantation - adverse effects; Kidney transplants; Magnesium Chloride - pharmacology; Medical research; Medicine; Metabolism; Mortality; Multicenter Studies as Topic; Nephrology; New Zealand; Organ transplant recipients; Peri-operative care; Perioperative Care - methods; Plasma; Postoperative Complications - epidemiology; Potassium Chloride - pharmacology; Pragmatic Clinical Trials as Topic; Public health; Quality of Life; Registries; Saline Solution - pharmacology; Sodium Acetate - pharmacology; Sodium Chloride - pharmacology; Study Protocol; Tissue Donors; Treatment Outcome; Australia; New Zealand; Sydney New South Wales Australia; Melbourne Victoria Australia; Adelaide South Australia Australia; End-stage kidney disease; Normal saline; Balanced crystalloid; Plasma-Lyte 148; Peri-operative care; Pragmatic trial; Registry trial; Delayed graft function; Intravenous fluids; Kidney transplantation

Delayed graft function, the requirement for dialysis due to poor kidney function post-transplant, is a frequent complication of deceased donor kidney transplantation and is associated with inferior outcomes and higher costs. Intravenous fluids given during and after transplantation may affect the ri...