Celiac disease: a comprehensive current review

• Published in: BMC medicine Vol. 17; no. 1; pp. 142 - 20
• Main Authors: Caio, Giacomo, Volta, Umberto, Sapone, Anna, Leffler, Daniel A., De Giorgio, Roberto, Catassi, Carlo, Fasano, Alessio
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.07.2019; BioMed Central; BMC
• Subjects: Adenocarcinoma; Alternative treatment; Antibodies; Autoimmunity; Biopsy; Celiac disease; Celiac Disease - diagnosis; Celiac Disease - epidemiology; Celiac Disease - immunology; Celiac Disease - therapy; Clinical phenotypes; Diagnosis; Diagnosis, Differential; Diet, Gluten-Free; Elderly patients; Epidemiology; Genes; Genetics; Gluten; Gluten-free diet; Health aspects; Histopathological findings; Humans; Immunity, Innate - physiology; Infection; Lymphomas; Metamorphosis (Biology); Microbiota (Symbiotic organisms); Peptides; Phenotype; Phenotypes; Quality of Life; Review; Risk factors; Serologic Tests; Tumors; Virus diseases; Women; Alternative treatment; Histopathological findings; Pathogenesis; Gluten-free diet; Genetics; Serological markers; Clinical phenotypes; Epidemiology

Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options. A major milestone in the history of celiac disease was the identification of tissue transglutaminase as the autoantigen, the...