Reduced activity of parvalbumin-positive interneurons in the posterior parietal cortex causes visually dominant multisensory decisions in freely navigating mice

• Published in: Molecular brain Vol. 15; no. 1; p. 82
• Main Authors: Choi, Ilsong, Lee, Seung-Hee
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.10.2022; BioMed Central; BMC
• Subjects: Animal behavior; Animals; Auditory Perception - physiology; Calcium; Calcium imaging; Cortex (parietal); Decision making; Fitness equipment; Hearing; In vivo calcium imaging; Information processing; Interneurons; Interneurons - metabolism; Mice; Micro Report; Multisensory integration; Neuroimaging; Neurons; Neurons - metabolism; Optogenetics; Parietal Lobe - physiology; Parvalbumin; Parvalbumin-positive neurons; Parvalbumins - metabolism; Peptides; Posterior parietal cortex; Sensory integration; Somatosensory cortex; Visual stimuli; Multisensory integration; Optogenetics; In vivo calcium imaging; Parvalbumin-positive neurons; Posterior parietal cortex

Multisensory integration is vital for animals to make optimal decisions in a complicated sensory environment. However, the neural mechanisms for flexible multisensory behaviors are not well understood. Here, we found that mice exhibit auditory-dominant decisions in the head-fixed and stationary stat...