A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

• Published in: Alzheimer's research & therapy Vol. 11; no. 1; pp. 71 - 16
• Main Authors: Del-Aguila, Jorge L., Li, Zeran, Dube, Umber, Mihindukulasuriya, Kathie A., Budde, John P., Fernandez, Maria Victoria, Ibanez, Laura, Bradley, Joseph, Wang, Fengxian, Bergmann, Kristy, Davenport, Richard, Morris, John C., Holtzman, David M., Perrin, Richard J., Benitez, Bruno A., Dougherty, Joseph, Cruchaga, Carlos, Harari, Oscar
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.08.2019; BioMed Central; BMC
• Subjects: Advertising executives; Alzheimer's disease; Banking industry; Banks (Finance); Best practices; Biochemistry; Brain; Care and treatment; Death; Gene expression; Gene mutation; Genes; Genetic aspects; Genetic research; Genetics; Nervous system diseases; Neurons; PSEN1; RNA; RNA sequencing; Single-nuclei RNA-seq; Tissue donation; Web-based brain molecular atlas; Single-nuclei RNA-seq; Web-based brain molecular atlas; PSEN1; Alzheimer’s disease

Alzheimer's disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genetic architecture...