Blood DNA methylation and COVID-19 outcomes

• Published in: Clinical epigenetics Vol. 13; no. 1; p. 118
• Main Authors: Balnis, Joseph, Madrid, Andy, Hogan, Kirk J., Drake, Lisa A., Chieng, Hau C., Tiwari, Anupama, Vincent, Catherine E., Chopra, Amit, Vincent, Peter A., Robek, Michael D., Singer, Harold A., Alisch, Reid S., Jaitovich, Ariel
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central Ltd 25.05.2021; BioMed Central
• Subjects: Acute respiratory distress syndrome; Age; Aged; Aged, 80 and over; Autoimmune diseases; Cell activation; Comparative analysis; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - mortality; CpG islands; Deoxyribonucleic acid; Disease; DNA; DNA methylation; DNA Methylation - physiology; Epidemics; Epigenetics; Female; Gene expression; Genes; Genetic research; Genomes; Genomics; Health aspects; Humans; Immune response; Infections; Intensive care; Male; Methylation; Middle Aged; Mortality; New York - epidemiology; Ontology; Pandemics; Patients; Prospective Studies; Regression analysis; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Signal transduction; Ventilators; Viral infections; Virus diseases; New York; COVID-19; DNA methylation; Gene expression; Acute respiratory distress syndrome (ARDS); Mortality; Outcomes

There are no prior reports that compare differentially methylated regions of DNA in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 pandemic using a shared epigenotyping platform. We performed a genome-wide analysis of circulating blood DNA CpG methylation using the I...