Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 94; no. 8; pp. 4171 - 4175
• Main Authors: Rondinone, C.M. (University of Goteborg, Sweden.), Wang, L.M, Lonnroth, P, Wesslau, C, Pierce, J.H, Smith, U
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 15.04.1997; National Acad Sciences; National Academy of Sciences; The National Academy of Sciences of the USA
• Subjects: ACTIVIDAD ENZIMATICA; ACTIVITE ENZYMATIQUE; Adipocytes; Adipocytes - metabolism; Animals; Antibodies; binding proteins; Biological Sciences; Body mass index; Cells, Cultured; Cellular biology; CELLULE; CELULAS; CIRCULACION SANGUINEA; CIRCULATION SANGUINE; CONTENIDO PROTEICO; CONTROL HORMONAL; CONTROLE HORMONAL; DIABETE; DIABETES; Diabetes mellitus; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - metabolism; enzyme activity; FOSFORILACION; GENERO HUMANO; GENRE HUMAIN; GLUCOSA; GLUCOSE; hormonal regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin resistance; INSULINA; INSULINE; Intracellular Signaling Peptides and Proteins; metabolism; Mice; nutrient transport; NUTRIENTES; Pharmacology; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphoproteins - metabolism; PHOSPHORYLATION; Phosphotransferases (Alcohol Group Acceptor); Phosphotransferases (Alcohol Group Acceptor) - metabolism; phosphotransferases (kinases); protein content; protein synthesis; PROTEINAS AGLUTINANTES; PROTEINE DE LIAISON; Proteins; Receptors; Signal Transduction; SINTESIS DE PROTEINAS; SUBSTANCE NUTRITIVE; SYNTHESE PROTEIQUE; TEJIDO ADIPOSO; TENEUR EN PROTEINES; TIROSINA; TISSU ADIPEUX; TRANSFERASAS; TRANSFERASE; Type 1 diabetes mellitus; Type 2 diabetes mellitus; TYROSINE

The large docking protein IRS-1 is a major substrate for the insulin receptor and other tyrosine kinases. It plays a key role in eliciting many of insulin's actions, including binding and activation of phosphatidylinositol (PI) 3-kinase and the subsequent increase in glucose transport. Gene dis...