Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series

Eleven adults with reverse transcriptase polymerase chain reaction-confirmed SARS-CoV-2 infection were admitted to the intensive care unit (ICU) at The University of Tokyo Hospital between April 6 and April 21, 2020, and treated with nafamostat mesylate in combination with favipiravir. [...]nafamost...

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Published inCritical care (London, England) Vol. 24; no. 1; p. 392
Main Authors Doi, Kent, Ikeda, Mahoko, Hayase, Naoki, Moriya, Kyoji, Morimura, Naoto
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 03.07.2020
BioMed Central
BMC
Subjects
Aged
Amides - therapeutic use
Benzamidines
Combination drug therapy
Coronavirus Infections - drug therapy
Coronaviruses
COVID-19
COVID-19 Drug Treatment
Critical care
Critical Illness
Critically ill persons
Drug therapy
Drug Therapy, Combination
Favipiravir
Female
Guanidines - therapeutic use
Humans
Influenza
Intensive care
Male
Methods
Middle Aged
Middle East respiratory syndrome
Mortality
Patients
Protease inhibitors
Pyrazines - therapeutic use
Research Letter
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Treatment Outcome
Ventilators
Viruses
Japan
Middle East
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Abstract Eleven adults with reverse transcriptase polymerase chain reaction-confirmed SARS-CoV-2 infection were admitted to the intensive care unit (ICU) at The University of Tokyo Hospital between April 6 and April 21, 2020, and treated with nafamostat mesylate in combination with favipiravir. [...]nafamostat mesylate therapy in combination with favipiravir may allow blockade of virus entry and replication, as well as inhibition of pathogenic host response, i.e., hyper-coagulopathy. Mechanical ventilation SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TMPRSS2: Transmembrane protease serine 2 VV-ECMO: Venovenous extracorporeal membrane oxygenation 1.
AbstractList Eleven adults with reverse transcriptase polymerase chain reaction-confirmed SARS-CoV-2 infection were admitted to the intensive care unit (ICU) at The University of Tokyo Hospital between April 6 and April 21, 2020, and treated with nafamostat mesylate in combination with favipiravir. [...]nafamostat mesylate therapy in combination with favipiravir may allow blockade of virus entry and replication, as well as inhibition of pathogenic host response, i.e., hyper-coagulopathy. Mechanical ventilation SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TMPRSS2: Transmembrane protease serine 2 VV-ECMO: Venovenous extracorporeal membrane oxygenation 1.
ArticleNumber 392
Audience Academic
Author Doi, Kent
Morimura, Naoto
Hayase, Naoki
Moriya, Kyoji
Ikeda, Mahoko
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  orcidid: 0000-0002-0115-1439
  surname: Doi
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  organization: Department of Acute Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. kdoi-tky@umin.ac.jp
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  organization: Department of Infection Control and Prevention, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
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  surname: Hayase
  fullname: Hayase, Naoki
  organization: Department of Acute Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
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  givenname: Kyoji
  surname: Moriya
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  surname: Morimura
  fullname: Morimura, Naoto
  organization: Department of Acute Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
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10.1128/AAC.01043-16
10.1128/AAC.00754-20
10.1016/S2665-9913(20)30121-1
10.1016/j.cell.2020.02.052
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Maehara, Hiromu
Shikama, Mio
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References 32811550 - Crit Care. 2020 Aug 18;24(1):511
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M Yamamoto (3078_CR2) 2016; 60
3078_CR3
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  publication-title: Cell
  doi: 10.1016/j.cell.2020.02.052
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Snippet Eleven adults with reverse transcriptase polymerase chain reaction-confirmed SARS-CoV-2 infection were admitted to the intensive care unit (ICU) at The...
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StartPage 392
SubjectTerms Aged
Amides - therapeutic use
Benzamidines
Combination drug therapy
Coronavirus Infections - drug therapy
Coronaviruses
COVID-19
COVID-19 Drug Treatment
Critical care
Critical Illness
Critically ill persons
Drug therapy
Drug Therapy, Combination
Favipiravir
Female
Guanidines - therapeutic use
Humans
Influenza
Intensive care
Male
Methods
Middle Aged
Middle East respiratory syndrome
Mortality
Patients
Protease inhibitors
Pyrazines - therapeutic use
Research Letter
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Treatment Outcome
Ventilators
Viruses
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Title Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series
URI https://www.ncbi.nlm.nih.gov/pubmed/32620147
https://www.proquest.com/docview/2424710110/abstract/
https://search.proquest.com/docview/2420152576
https://pubmed.ncbi.nlm.nih.gov/PMC7332736
https://doaj.org/article/80eedbb089b84f8cba2b29563792cb98
Volume 24
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