Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture

• Published in: TheScientificWorld Vol. 2014; no. 2014; pp. 1 - 15
• Main Authors: Li, Guang-Rong, Meng, Ze-Bing, Kang, Ji-Chuan, Wen, Ting-Chi, Kang, Chao, Hyde, Kevin D.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2014; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Adenosine; Ascomycota; Biology; Bioreactors; Carbon; Chemical properties; Chinese medicine; Cordyceps - growth & development; Cordyceps - metabolism; Deoxyadenosines - biosynthesis; Experiments; Fermentation; Fungi; Identification and classification; Industrial Microbiology - instrumentation; Industrial Microbiology - methods; Optimization; Physiological aspects; Science; Studies; Sucrose

Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato, but it is hard to produce large amounts of this substance in industrial production. In this work, single factor design, Plackett-Burman design, and central composite design were employed to estab...