Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children

• Published in: Immunity & ageing Vol. 18; no. 1; p. 11
• Main Authors: Dobbs, Katherine R, Embury, Paula, Koech, Emmily, Ogolla, Sidney, Munga, Stephen, Kazura, James W, Dent, Arlene E
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.03.2021; BioMed Central; BMC
• Subjects: Age; Ageing; Aging; Antigen presentation; Asymptomatic; Children; CpG islands; Cytokines; Deoxyribonucleic acid; DNA; DNA methylation; Epigenetic; Epigenetic inheritance; Epigenetics; Gene expression; Genes; Genomes; Geriatrics; Immune response; Immune system; Inflammation; Innate immune; Innate immunity; Interleukin 10; Interleukin 12; Interleukin 8; Malaria; Methylation; Monocyte; Monocytes; Principal components analysis; TLR2 protein; TLR4 protein; Toll-like receptors; Transcription; Young adults; Kenya; Aging; DNA methylation; Innate immune; Epigenetic; Monocyte; Ageing

Age-related changes in adaptive and innate immune cells have been associated with a decline in effective immunity and chronic, low-grade inflammation. Epigenetic, transcriptional, and functional changes in monocytes occur with aging, though most studies to date have focused on differences between yo...