Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation - Weiße, Jonas; Rosemann, Julia; Müller, Lisa; Kappler, Matthias; Eckert, Alexander W.; Glaß, Markus; Misiak, Danny; Hüttelmaier, Stefan; Ballhausen, Wolfgang G.; Hatzfeld, Mechthild; Haemmerle, Monika; Gutschner, Tony (Molecular cancer, 2021)
Keywords: Adherens junctions; Analysis; Antineoplastic Agents - pharmacology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Cell culture; Cell differentiation; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - genetics; Clonal heterogeneity; Dasatinib; Dasatinib - pharmacology; EMT; Gene expression; Health aspects; HNSCC; Humans; Invasion; Invasiveness; ITH; Kinases; Lck protein; Lethality; Leukocyte migration; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics; Lymphocytes; Metastases; Metastasis; Motility; Mouth cancer; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Oral cancer; Phenols; Protein-tyrosine kinase; Proteins; RNA; Scientific equipment and supplies industry; Therapeutic targets; Tongue; Transcriptome; Transcriptomes; Tumor cell lines; Tumors; Tyrosine; United States; New York; United States--US; Dasatinib; OSCC; Src; HNSCC; Clonal heterogeneity; Metastasis; ITH; EMT; Invasion