DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation

• Published in: Journal of experimental & clinical cancer research Vol. 38; no. 1; pp. 350 - 13
• Main Authors: Cui, Haoran, Wang, Qin, Lei, Zhenchuan, Feng, Maoxiao, Zhao, Zhongxi, Wang, Yunshan, Wei, Guangwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.08.2019; BioMed Central; BMC
• Subjects: Animal experimentation; Animals; Apoptosis; Apoptosis Regulatory Proteins - chemistry; Apoptosis Regulatory Proteins - metabolism; Biochemistry; Cancer; Cancer cells; Cancer development; Care and treatment; Cell death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Computational Biology - methods; CUL4A; Development and progression; Disease Models, Animal; DTL; Fluorescent antibody technique; Genes; Genetic aspects; Heterografts; Humans; Ligases; Mass spectrometry; Messenger RNA; Mice; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Nuclear Proteins - chemistry; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; PDCD4; Phenotypes; Polymerase chain reaction; Proteasome Endopeptidase Complex - metabolism; Proteins; Proteolysis; RNA; RNA-Binding Proteins - chemistry; RNA-Binding Proteins - metabolism; Spectroscopy; Structure-Activity Relationship; Tumors; Ubiquitin; Ubiquitin-proteasome system; Ubiquitination; Ubiquitins - metabolism; Wound care; Wound healing; CUL4A; PDCD4; Cancer development; DTL

Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may involve in the process of cancer development. Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in cell apoptosis, transformation, inva...