Unfolded Protein Response Signaling in Liver Disorders: A 2023 Updated Review

• Published in: International journal of molecular sciences Vol. 24; no. 18; p. 14066
• Main Authors: Shreya, Smriti, Grosset, Christophe F., Jain, Buddhi Prakash
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 14.09.2023; MDPI
• Subjects: Alzheimer's disease; B cells; Biochemistry, Molecular Biology; Biosensors; Carbohydrates; Cellular Biology; Chemical bonds; Development and progression; Endoplasmic reticulum; Enzymes; Fatty liver; Genes; Genetic transcription; Health aspects; Hepatitis; Homeostasis; Inositol; Kinases; Life Sciences; Liver; Liver cancer; Localization; Medical research; Medicine, Experimental; Membrane proteins; Metabolism; Molecular biology; Neurophysiology; Phosphorylation; Physiological aspects; Polypeptides; Protein biosynthesis; Protein folding; Protein kinases; Review; Ribonucleic acid; RNA; Sensors; Transcription factors; Virus diseases; Well being; unfolded protein response; non-alcoholic fatty liver disease; liver disorders; endoplasmic reticulum; hepatocellular carcinoma
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms241814066

Endoplasmic reticulum (ER) is the site for synthesis and folding of secreted and transmembrane proteins. Disturbance in the functioning of ER leads to the accumulation of unfolded and misfolded proteins, which finally activate the unfolded protein response (UPR) signaling. The three branches of UPR—...