Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

• Published in: Journal of biomedical science Vol. 27; no. 1; pp. 49 - 23
• Main Authors: Wu, Yi-Ying, Kuo, Hung-Chih
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.04.2020; BioMed Central; BMC
• Subjects: Alzheimer's disease; Amyotrophic lateral sclerosis; Analysis; Animal models; Antisense therapy; Apoptosis; Binding sites; Biomarkers; Central nervous system (CNS); Development and progression; Diagnostic systems; Disease; Drug development; Etiology; Gene expression; Life span; Long non-coding RNAs (lncRNAs); Mammalian cells; MicroRNA; MicroRNAs; MicroRNAs (miRNAs); miRNA; Motor neuron diseases; Motor neurone disease; Movement disorders; Mutation; Nervous system diseases; Networks; Neurodegeneration; Neurodegenerative diseases; Neurons; Non-coding RNA; Noncoding RNAs (ncRNAs); Parkinson's disease; Pathogenesis; Phenotypes; Proteins; Review; Senile plaques; Synuclein; Tau protein; Therapeutics; Long non-coding RNAs (lncRNAs); Alzheimer’s disease (AD); MicroRNAs (miRNAs); Motor neuron diseases; Neurodegenerative diseases; Huntington’s disease (HD); Parkinson’s disease (PD); Central nervous system (CNS); Noncoding RNAs (ncRNAs)

Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific expression patterns. Moreover, ncRNAs have been found to intricately and dynamically regulate various signaling pathways in ne...