Association between human blood metabolome and the risk of breast cancer

• Published in: Breast cancer research : BCR Vol. 25; no. 1; pp. 9 - 11
• Main Authors: Wang, Yu, Liu, Fanghua, Sun, Lulu, Jia, Yiming, Yang, Pinni, Guo, Daoxia, Shi, Mengyao, Wang, Aili, Chen, Guo-Chong, Zhang, Yonghong, Zhu, Zhengbao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.01.2023; BioMed Central; BMC
• Subjects: Acetates; Acetic acid; Biobanks; Biomarkers; Blood; Breast cancer; Breast Neoplasms - etiology; Breast Neoplasms - genetics; Cancer; Cancer therapies; Care and treatment; Cholesterol; Cholesterol, HDL - genetics; Circulatory system; Clinical trials; Collaboration; Consortia; Development and progression; Disease; Female; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Health aspects; High density lipoprotein; Humans; Mendelian randomization; Mental disorders; Mental illness; Metabolism; Metabolites; Metabolome; NMR; Nuclear magnetic resonance; Oncology, Experimental; Polymorphism, Single Nucleotide; Prevention; Risk Factors; Side effects; Statistical power; Therapeutic targets; Triglycerides; United Kingdom > UK; Metabolites; Breast cancer; Mendelian randomization

Breast cancer is the most common cancer among women with limited treatment options. To identify promising drug targets for breast cancer, we conducted a systematical Mendelian randomization (MR) study to screen blood metabolome for potential causal mediators of breast cancer and further predict targ...