1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development

• Published in: Developmental cell Vol. 56; no. 22; pp. 3128 - 3145.e15
• Main Authors: Wang, Ting, Wang, Zheng, de Fabritus, Lauriane, Tao, Jinglian, Saied, Essa M., Lee, Ho-Joon, Ramazanov, Bulat R., Jackson, Benjamin, Burkhardt, Daniel, Parker, Mikhail, Gleinich, Anne S., Wang, Zhirui, Seo, Dong Eun, Zhou, Ting, Xu, Shihao, Alecu, Irina, Azadi, Parastoo, Arenz, Christoph, Hornemann, Thorsten, Krishnaswamy, Smita, van de Pavert, Serge A., Kaech, Susan M., Ivanova, Natalia B., Santori, Fabio R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.11.2021; Elsevier
• Subjects: 1-deoxysphingosine; Animals; cardiomyocyte; Cell Differentiation - drug effects; Cell Differentiation - physiology; COUP-TF; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Humans; Life Sciences; lymphatic; Lymphatic Vessels - drug effects; metabolism; Mice; NR2F1; NR2F2; NR2F6; Organogenesis - drug effects; Organogenesis - physiology; Repressor Proteins - physiology; sphingolipid; Sphingolipids - pharmacology; SPTLC2; SPTLC2; sphingolipid; cardiomyocyte; NR2F1; metabolism; NR2F2; COUP-TF; 1-deoxysphingosine; NR2F6; lymphatic

Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and prod...