1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and prod...
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| Published in | Developmental cell Vol. 56; no. 22; pp. 3128 - 3145.e15 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
22.11.2021
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for development of the nervous system, heart, veins, and lymphatic vessels. We show that these non-canonical alanine-based sphingolipids bind to the NR2F1/2 ligand-binding domains (LBDs) and modulate their transcriptional activity in cell-based assays at physiological concentrations. Furthermore, inhibition of sphingolipid biosynthesis phenocopies NR2F1/2 deficiency in endothelium and cardiomyocytes, and increases in 1-deoxysphingosine levels activate NR2F1/2-dependent differentiation programs. Our findings suggest that 1-deoxysphingosines are physiological regulators of NR2F1/2-mediated transcription.
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•1-deoxyphingosines bind and modulate NR2F1 and NR2F2 transcriptional activity•Genetic deletion of Sptlc2 phenocopies Nr2f2 deficiency in lymphatic development•Inhibition of sphingolipid synthesis impairs human cardiomyocyte differentiation•1-deoxysphingosine supplementation promotes human cardiomyocyte maturation
Wang et al. identify 1-deoxysphingosines as modulators of COUP-TF activity. Inhibition of sphingolipid biosynthesis mimics COUP-TF knockout phenotypes in lymphatic development and in human ESC-derived cardiomyocytes, whereas elevated levels of 1-deoxysphingosines enhance cardiomyocyte differentiation. Thus, sphingolipids could be physiological ligands for COUP-TFs and could play a critical role in development. |
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| AbstractList | Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for development of the nervous system, heart, veins, and lymphatic vessels. We show that these non-canonical alanine-based sphingolipids bind to the NR2F1/2 ligand-binding domains (LBDs) and modulate their transcriptional activity in cell-based assays at physiological concentrations. Furthermore, inhibition of sphingolipid biosynthesis phenocopies NR2F1/2 deficiency in endothelium and cardiomyocytes, and increases in 1-deoxysphingosine levels activate NR2F1/2-dependent differentiation programs. Our findings suggest that 1-deoxysphingosines are physiological regulators of NR2F1/2-mediated transcription.
[Display omitted]
•1-deoxyphingosines bind and modulate NR2F1 and NR2F2 transcriptional activity•Genetic deletion of Sptlc2 phenocopies Nr2f2 deficiency in lymphatic development•Inhibition of sphingolipid synthesis impairs human cardiomyocyte differentiation•1-deoxysphingosine supplementation promotes human cardiomyocyte maturation
Wang et al. identify 1-deoxysphingosines as modulators of COUP-TF activity. Inhibition of sphingolipid biosynthesis mimics COUP-TF knockout phenotypes in lymphatic development and in human ESC-derived cardiomyocytes, whereas elevated levels of 1-deoxysphingosines enhance cardiomyocyte differentiation. Thus, sphingolipids could be physiological ligands for COUP-TFs and could play a critical role in development. Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for development of the nervous system, heart, veins, and lymphatic vessels. We show that these non-canonical alanine-based sphingolipids bind to the NR2F1/2 ligand-binding domains (LBDs) and modulate their transcriptional activity in cell-based assays at physiological concentrations. Furthermore, inhibition of sphingolipid biosynthesis phenocopies NR2F1/2 deficiency in endothelium and cardiomyocytes, and increases in 1-deoxysphingosine levels activate NR2F1/2-dependent differentiation programs. Our findings suggest that 1-deoxysphingosines are physiological regulators of NR2F1/2-mediated transcription. Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of NR2F1/2 (COUP-TFs) activity, which are orphan NHRs critical for development of the nervous system, heart, veins, and lymphatic vessels. We show that these non-canonical alanine-based sphingolipids bind to the NR2F1/2 ligand binding domains (LBDs) and modulate their transcriptional activity in cell-based assays at physiological concentrations. Furthermore, inhibition of sphingolipid biosynthesis phenocopies NR2F1/2 deficiency in endothelium and cardiomyocytes, while increases in 1-deoxysphingosine levels activate NR2F1/2-dependent differentiation programs. Our findings suggest that 1-deoxysphingosines are found in tissues at concentrations high enough to have a physiological function as regulators of NR2F1/2-mediated transcription. 1-deoxysphingosines are physiological modulators of COUP-TFs. Wang et al identify 1-deoxysphingosines as modulator of COUP-TF activity. Inhibition of sphingolipid biosynthesis mimics COUP-TF knockout phenotypes in lymphatic development and in human ESC-derived cardiomyocytes whereas elevated levels of 1-deoxysphingosines enhance cardiomyocyte differentiation. Thus, sphingolipids could be physiological ligands for COUP-TFs with a critical role in development. |
| Author | Wang, Ting Alecu, Irina Tao, Jinglian Arenz, Christoph Wang, Zheng Kaech, Susan M. Seo, Dong Eun Lee, Ho-Joon Jackson, Benjamin Parker, Mikhail Zhou, Ting Ivanova, Natalia B. de Fabritus, Lauriane Burkhardt, Daniel Gleinich, Anne S. Krishnaswamy, Smita Hornemann, Thorsten Ramazanov, Bulat R. Wang, Zhirui van de Pavert, Serge A. Santori, Fabio R. Saied, Essa M. Xu, Shihao Azadi, Parastoo |
| AuthorAffiliation | 7 Institut für Chemie, Humboldt Universität zu Berlin, Berlin 12489, Germany 11 Department of Cell Biology, Yale University, New Haven, CT 06520, USA 3 Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong 266071, China 15 Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, CH-8091, Switzerland 6 Center for Molecular Medicine, Department of Genetics, University of Georgia, Athens, GA 30602, USA 2 Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China 5 Aix-Marseille University, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy, 13288 Marseille Cedex 9, France 4 Department of Reproductive Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China 8 Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt 10 Center for Genome Analysis, Yale University, New Haven, CT 06510, USA 1 Department of Immunobiology, Yale Un |
| AuthorAffiliation_xml | – name: 6 Center for Molecular Medicine, Department of Genetics, University of Georgia, Athens, GA 30602, USA – name: 7 Institut für Chemie, Humboldt Universität zu Berlin, Berlin 12489, Germany – name: 12 Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA – name: 3 Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong 266071, China – name: 2 Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China – name: 4 Department of Reproductive Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China – name: 11 Department of Cell Biology, Yale University, New Haven, CT 06520, USA – name: 16 Lead contact – name: 5 Aix-Marseille University, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy, 13288 Marseille Cedex 9, France – name: 1 Department of Immunobiology, Yale University, New Haven, CT 06520, USA – name: 9 Department of Genetics, Yale University, New Haven, CT 06520, USA – name: 13 NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA – name: 15 Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, CH-8091, Switzerland – name: 8 Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt – name: 10 Center for Genome Analysis, Yale University, New Haven, CT 06510, USA – name: 14 Neural Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, K1H 8M5, Canada |
| Author_xml | – sequence: 1 givenname: Ting surname: Wang fullname: Wang, Ting organization: Department of Immunobiology, Yale University, New Haven, CT 06520, USA – sequence: 2 givenname: Zheng surname: Wang fullname: Wang, Zheng organization: Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong 266071, China – sequence: 3 givenname: Lauriane surname: de Fabritus fullname: de Fabritus, Lauriane organization: Aix-Marseille Universite, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex 9, France – sequence: 4 givenname: Jinglian surname: Tao fullname: Tao, Jinglian organization: Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China – sequence: 5 givenname: Essa M. surname: Saied fullname: Saied, Essa M. organization: Institut für Chemie, Humboldt Universität zu Berlin, Berlin 12489, Germany – sequence: 6 givenname: Ho-Joon surname: Lee fullname: Lee, Ho-Joon organization: Department of Genetics, Yale University, New Haven, CT 06520, USA – sequence: 7 givenname: Bulat R. surname: Ramazanov fullname: Ramazanov, Bulat R. organization: Department of Cell Biology, Yale University, New Haven, CT 06520, USA – sequence: 8 givenname: Benjamin surname: Jackson fullname: Jackson, Benjamin organization: Center for Molecular Medicine, Department of Genetics, University of Georgia, Athens, GA 30602, USA – sequence: 9 givenname: Daniel surname: Burkhardt fullname: Burkhardt, Daniel organization: Department of Genetics, Yale University, New Haven, CT 06520, USA – sequence: 10 givenname: Mikhail surname: Parker fullname: Parker, Mikhail organization: Center for Molecular Medicine, Department of Genetics, University of Georgia, Athens, GA 30602, USA – sequence: 11 givenname: Anne S. surname: Gleinich fullname: Gleinich, Anne S. organization: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA – sequence: 12 givenname: Zhirui surname: Wang fullname: Wang, Zhirui organization: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA – sequence: 13 givenname: Dong Eun surname: Seo fullname: Seo, Dong Eun organization: Center for Molecular Medicine, Department of Genetics, University of Georgia, Athens, GA 30602, USA – sequence: 14 givenname: Ting surname: Zhou fullname: Zhou, Ting organization: Department of Immunobiology, Yale University, New Haven, CT 06520, USA – sequence: 15 givenname: Shihao surname: Xu fullname: Xu, Shihao organization: NOMIS Center for Immunobiology and Microbial Pathogenesis, the Salk Institute for Biological Studies, La Jolla, CA 92037, USA – sequence: 16 givenname: Irina surname: Alecu fullname: Alecu, Irina organization: Neural Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa K1H 8M5, Canada – sequence: 17 givenname: Parastoo surname: Azadi fullname: Azadi, Parastoo organization: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA – sequence: 18 givenname: Christoph surname: Arenz fullname: Arenz, Christoph organization: Institut für Chemie, Humboldt Universität zu Berlin, Berlin 12489, Germany – sequence: 19 givenname: Thorsten surname: Hornemann fullname: Hornemann, Thorsten organization: Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich 8091, Switzerland – sequence: 20 givenname: Smita surname: Krishnaswamy fullname: Krishnaswamy, Smita organization: Department of Genetics, Yale University, New Haven, CT 06520, USA – sequence: 21 givenname: Serge A. surname: van de Pavert fullname: van de Pavert, Serge A. organization: Aix-Marseille Universite, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex 9, France – sequence: 22 givenname: Susan M. surname: Kaech fullname: Kaech, Susan M. email: skaech@salk.edu organization: NOMIS Center for Immunobiology and Microbial Pathogenesis, the Salk Institute for Biological Studies, La Jolla, CA 92037, USA – sequence: 23 givenname: Natalia B. surname: Ivanova fullname: Ivanova, Natalia B. email: natalia.ivanova@uga.edu organization: Center for Molecular Medicine, Department of Genetics, University of Georgia, Athens, GA 30602, USA – sequence: 24 givenname: Fabio R. surname: Santori fullname: Santori, Fabio R. email: fabio.santori@yale.edu organization: Department of Immunobiology, Yale University, New Haven, CT 06520, USA |
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| CitedBy_id | crossref_primary_10_1016_j_yjmcc_2023_01_007 crossref_primary_10_1186_s12967_023_04049_y crossref_primary_10_1038_s41580_024_00742_y crossref_primary_10_1128_jvi_00664_23 crossref_primary_10_1016_j_isci_2022_105750 crossref_primary_10_1016_j_stem_2024_03_011 crossref_primary_10_3389_fcell_2022_949013 |
| Cites_doi | 10.1016/S0021-9258(18)64849-5 10.1194/jlr.M300005-JLR200 10.1242/dev.01808 10.1016/j.ydbio.2008.06.034 10.1371/journal.pone.0008910 10.1038/nmeth.3047 10.1128/MCB.15.12.6736 10.1194/jlr.M067033 10.1016/j.ydbio.2003.10.038 10.1101/gad.11.15.1925 10.1101/gad.16974811 10.1016/j.immuni.2008.06.008 10.1194/jlr.M072421 10.1016/j.devcel.2004.12.014 10.1074/jbc.M109.091710 10.1523/JNEUROSCI.2536-09.2009 10.1016/j.ab.2004.04.031 10.1021/ac051437y 10.1016/0925-4773(94)90098-1 10.1194/jlr.M700414-JLR200 10.1210/en.2018-00081 10.1016/j.ajhg.2010.09.010 10.1074/jbc.M112.428185 10.1073/pnas.1420701112 10.1038/355359a0 10.1038/383728a0 10.1016/j.bpj.2008.12.3926 10.1371/journal.pcbi.1003559 10.1038/nature03511 10.1016/j.cmet.2012.06.004 10.1016/0092-8674(90)90737-Y 10.1172/JCI40101 10.1016/j.bmc.2018.06.031 10.1016/0092-8674(92)90479-V 10.1074/jbc.M209706200 10.1021/acschembio.6b00593 10.1101/gad.13.8.1037 10.1021/cr2002917 10.1016/j.stem.2017.12.002 10.1016/j.cell.2011.09.045 10.1371/journal.pbio.0060227 10.1523/JNEUROSCI.3181-11.2011 10.1016/j.ajhg.2014.01.002 10.1371/journal.pone.0175776 10.1016/j.cmet.2013.06.015 10.1074/jbc.M111.296947 10.1016/j.cmet.2015.01.004 10.1016/j.cmet.2013.01.003 10.1210/en.2006-0355 10.1089/lrb.2013.0053 10.1038/nbt1383 10.1101/gad.1588407 10.1016/j.cell.2019.01.036 10.1016/j.cell.2008.03.034 10.1016/j.stem.2012.02.016 10.1016/S0021-9258(18)35871-X 10.1074/jbc.M109.023192 10.15252/msb.20188746 10.1128/MCB.19.4.2734 10.1038/s41467-018-07333-4 10.1074/jbc.M114.603860 10.1172/JCI58050 10.1126/science.284.5418.1362 10.1172/JCI57549 10.1093/nar/gkw1092 10.1126/science.1260419 10.1016/S0925-4773(01)00509-3 10.1242/dev.040568 10.1038/nature09978 10.1186/s13059-017-1382-0 10.1242/dev.129.19.4509 10.3390/ijms22158171 10.1074/jbc.M109.042028 10.1016/j.cell.2014.10.010 10.1006/bbrc.1995.1827 10.1242/dev.02229 10.2144/btn-2018-0115 10.1038/nature09002 10.1016/j.ydbio.2004.07.037 10.1038/nbt1210-1248 10.1126/science.284.5418.1365 10.1056/NEJMoa1815111 10.1021/bi00401a051 10.1093/ilar/ilx013 10.1038/nprot.2012.150 10.1038/330624a0 10.1038/nmeth.2999 10.1136/bmjdrc-2014-000073 10.1073/pnas.2002391117 10.1016/j.ajhg.2014.03.007 10.1126/science.1106943 10.1038/330444a0 10.1021/ac4039652 10.1073/pnas.91.10.4451 10.1016/j.jaut.2012.07.007 10.1126/science.1247005 10.3390/cells9122606 10.1016/j.stemcr.2017.10.024 10.1242/dev.02512 10.1074/jbc.M109.092973 10.1038/355262a0 10.1038/s41587-019-0336-3 10.1038/ncomms2248 10.1101/gad.1859310 10.1016/j.devcel.2013.04.017 |
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| Copyright | 2021 Elsevier Inc. Copyright © 2021 Elsevier Inc. All rights reserved. Distributed under a Creative Commons Attribution 4.0 International License |
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| Keywords | SPTLC2 sphingolipid cardiomyocyte NR2F1 metabolism NR2F2 COUP-TF 1-deoxysphingosine NR2F6 lymphatic |
| Language | English |
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| Notes | These authors contributed equally. Conceptualization, methodology, writing, review and editing: FRS, NBI. Supervision and project administration: FRS, NBI and SMK. Investigation and validation: TW, LF, ZW, JT, BRR, BJ, TZ, AG, ZhiW, PA, SX, MP, DES, TH, CA, EMS, IA, and SvP, NBI, FRS. Resources: ZW, JT, TH, CA, EMS and IA. Formal data analysis and curation: NBI, BRR, HJL, DB and SK. Author contributions |
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| References | Starkey, Li, Drenkhahn-Weinaug, Liu, Lubahn (bib88) 2018; 159 Burridge, Matsa, Shukla, Lin, Churko, Ebert, Lan, Diecke, Huber, Mordwinkin (bib6) 2014; 11 Kanatani, Honda, Aramaki, Hayashi, Kubo, Ishida, Tanaka, Kawauchi, Sekine, Kusuzawa (bib30) 2015; 112 Hanada, Nishijima, Kiso, Hasegawa, Fujita, Ogawa, Akamatsu (bib20) 1992; 267 Merrill (bib47) 2011; 111 Qiu, Cooney, Kuratani, DeMayo, Tsai, Tsai (bib67) 1994; 91 Qiu, Pereira, DeMayo, Lydon, Tsai, Tsai (bib68) 1997; 11 Othman, Saely, Muendlein, Vonbank, Drexel, von Eckardstein, Hornemann (bib58) 2015; 3 Walker, Jacobs, Watts, Rottiers, Jiang, Finnegan, Shioda, Hansen, Yang, Niebergall (bib99) 2011; 147 Fyrst, Zhang, Herr, Byun, Bittman, Phan, Harris, Saba (bib15) 2008; 49 Bazigou, Lyons, Smith, Venn, Cope, Brown, Makinen (bib3) 2011; 121 Ponzielli, Astier, Chartier, Gallet, Thérond, Sémériva (bib66) 2002; 129 Penno, Reilly, Houlden, Laurá, Rentsch, Niederkofler, Stoeckli, Nicholson, Eichler, Brown (bib61) 2010; 285 Mlodzik, Hiromi, Weber, Goodman, Rubin (bib51) 1990; 60 Wang, Zhang, Lee, Ivanova (bib103) 2019; 66 Luecken, Theis (bib44) 2019; 15 Tang, Xie, Park, Jamrich, Tsai, Tsai (bib92) 2010; 137 Smith, Want, O'Maille, Abagyan, Siuzdak (bib84) 2006; 78 Takamoto, You, Moses, Chiang, Zimmer, Schwartz, DeMayo, Tsai, Tsai (bib91) 2005; 132 Petersen, Watson, Richmond, Sarov, Walthall, Miller (bib63) 2011; 31 Srinivasan, Dillard, Lagutin, Lin, Tsai, Tsai, Samokhvalov, Oliver (bib85) 2007; 21 Li, Li, Chakraborty, Fan, Bui, Peake, Kuo, Xiao, Cao, Jiang (bib38) 2009; 284 Alecu, Othman, Penno, Saied, Arenz, von Eckardstein, Hornemann (bib2) 2017; 58 Shakoury-Elizeh, Protchenko, Berger, Cox, Gable, Dunn, Prinz, Bard, Philpott (bib81) 2010; 285 Russo, Tidhar, Futerman, Cowart (bib72) 2013; 288 Steiner, Saied, Othman, Arenz, Maccarone, Poad, Blanksby, von Eckardstein, Hornemann (bib90) 2016; 57 Al Turki, Manickaraj, Mercer, Gerety, Hitz, Lindsay, D'Alessandro, Swaminathan, Bentham, Arndt (bib1) 2014; 94 Montemayor, Montemayor, Ridgeway, Lin, Wheeler, Pletcher, Pereira (bib53) 2010; 5 Giguere, Ong, Segui, Evans (bib19) 1987; 330 Parks, Blanchard, Bledsoe, Chandra, Consler, Kliewer, Stimmel, Willson, Zavacki, Moore, Lehmann (bib60) 1999; 284 Petkovich, Brand, Krust, Chambon (bib64) 1987; 330 Pipaón, Tsai, Tsai (bib65) 1999; 19 Janowski, Willy, Devi, Falck, Mangelsdorf (bib26) 1996; 383 Santori, Huang, van de Pavert, Douglass, Leaver, Haubrich, Keber, Lorbek, Konijn, Rosales (bib77) 2015; 21 Lee, Huang, Kropat, Henras, Merchant, Dickson, Chanfreau (bib36) 2012; 16 Mwinyi, Boström, Fehrer, Othman, Waeber, Marti-Soler, Vollenweider, Marques-Vidal, Schiöth, von Eckardstein, Hornemann (bib55) 2017; 12 Schwach, Verkerk, Mol, Monshouwer-Kloots, Devalla, Orlova, Anastassiadis, Mummery, Davis, Passier (bib80) 2017; 9 Gantner, Eade, Wallace, Handzlik, Fallon, Trombley, Bonelli, Giles, Harkins-Perry, Heeren (bib16) 2019; 381 Uhlen, Oksvold, Fagerberg, Lundberg, Jonasson, Forsberg, Zwahlen, Kampf, Wester, Hober (bib96) 2010; 28 van Westen, Gaulton, Overington (bib98) 2014; 10 Kanai, Okabe, Hiromi (bib29) 2005; 8 Lee, Kim, Hu, Khan, Kim, Bharadwaj, Davidson, Choi, Shin, Lee (bib35) 2012; 287 Bosch, Boonstra, Gonzaga-Jauregui, Xu, de Ligt, Jhangiani, Wiszniewski, Muzny, Yntema, Pfundt (bib4) 2014; 94 Molina, Cripps (bib52) 2001; 109 Tao, Seo, Jackson, Ivanova, Santori (bib93) 2020; 9 Uhlén, Fagerberg, Hallström, Lindskog, Oksvold, Mardinoglu, Sivertsson, Kampf, Sjöstedt, Asplund (bib95) 2015; 347 Gauchat, Escriva, Miljkovic-Licina, Chera, Langlois, Begue, Laudet, Galliot (bib18) 2004; 275 Moon, van Dijk, Wang, Gigante, Burkhardt, Chen, Yim, Elzen, Hirn, Coifman (bib54) 2019; 37 Stehling, Mascarenhas, Vashisht, Sheftel, Niggemeyer, Rösser, Pierik, Wohlschlegel, Lill (bib89) 2013; 18 Zelhof, Yao, Chen, Evans, McKeown (bib108) 1995; 15 Srinivasan, Geng, Yang, Wang, Mukatira, Studer, Porto, Lagutin, Oliver (bib86) 2010; 24 Shalem, Sanjana, Hartenian, Shi, Scott, Mikkelson, Heckl, Ebert, Root, Doench, Zhang (bib82) 2014; 343 Hornemann, Penno, Rütti, Ernst, Kivrak-Pfiffner, Rohrer, von Eckardstein (bib24) 2009; 284 Wolf, Angerer, Theis (bib104) 2018; 19 Sayin, Wahlström, Felin, Jäntti, Marschall, Bamberg, Angelin, Hyötyläinen, Orešič, Bäckhed (bib79) 2013; 17 Jonk, de Jonge, Pals, Wissink, Vervaart, Schoorlemmer, Kruijer (bib27) 1994; 47 Pereira, Qiu, Zhou, Tsai, Tsai (bib62) 1999; 13 Rotthier, Auer-Grumbach, Janssens, Baets, Penno, Almeida-Souza, Van Hoof, Jacobs, De Vriendt, Schlotter-Weigel (bib71) 2010; 87 Saied, Le, Hornemann, Arenz (bib74) 2018; 26 Revankar, Cimino, Sklar, Arterburn, Prossnitz (bib70) 2005; 307 Fyrst, Herr, Harris, Saba (bib14) 2004; 45 Fu, Coulter, Yoshihara, Oh, Fang, Cayabyab, Zhu, Zhang, Leblanc, Liu (bib13) 2019; 176 Eppig (bib9) 2017; 58 Shan, Walthall (bib83) 2008; 322 Kruse, Suino-Powell, Zhou, Kretschman, Reynolds, Vonrhein, Xu, Wang, Tsai, Tsai, Xu (bib33) 2008; 6 You, Lin, Lee, DeMayo, Tsai, Tsai (bib107) 2005; 435 Saito, Chang, Horikawa, Hatsugai, Higuchi, Hashida, Yoshida, Matsuda, Arai, Nagai (bib75) 2012; 3 Jordan-Williams, Ruddell (bib28) 2014; 12 Garofalo, Penno, Schmidt, Lee, Frosch, von Eckardstein, Brown, Hornemann, Eichler (bib17) 2011; 121 Merrill, Wang, Mullins (bib48) 1988; 27 Mettler, Vogler, Urban (bib49) 2006; 133 Wang, Oron, Nelson, Razis, Ivanova (bib102) 2012; 10 Lo, Aulabaugh, Jin, Cowling, Bard, Malamas, Ellestad (bib42) 2004; 332 Narayanaswamy, Shinde, Sulc, Kraut, Staples, Thiam, Grimm, Sellergren, Torta, Wenk (bib56) 2014; 86 Burkhardt, Stanley, Perdigoto, Gigante, Herold, Wolf, Giraldez, van Dijk, Krishnaswamy (bib5) 2019 Lian, Zhang, Azarin, Zhu, Hazeltine, Bao, Hsiao, Kamp, Palecek (bib39) 2013; 8 Tsai, Tsai (bib94) 1997; 18 Kawamata, Fujii, Hosoya, Harada, Yoshida, Miwa, Fukusumi, Habata, Itoh, Shintani (bib32) 2003; 278 Wu, Cheng, Lanz, Wang, Respress, Ather, Chen, Tsai, Wehrens, Tsai, Tsai (bib105) 2013; 25 Saied, Arenz (bib73) 2021; 22 Sasaki, Arai, Cocco, White (bib78) 2009; 96 Eichler, Hornemann, McCampbell, Kuljis, Penno, Vardeh, Tamrazian, Garofalo, Lee, Kini (bib8) 2009; 29 Makishima, Okamoto, Repa, Tu, Learned, Luk, Hull, Lustig, Mangelsdorf, Shan (bib45) 1999; 284 Yamaguchi, Zhou, Lin, Durand, Tsai, Tsai (bib106) 2004; 266 Miyake, Kozutsumi, Nakamura, Fujita, Kawasaki (bib50) 1995; 211 Churko, Garg, Treutlein, Venkatasubramanian, Wu, Lee, Wessells, Chen, Chen, Chetal (bib7) 2018; 9 Lone, Hülsmeier, Saied, Karsai, Arenz, von Eckardstein, Hornemann (bib43) 2020; 117 Hermann-Kleiter, Gruber, Lutz-Nicoladoni, Thuille, Fresser, Labi, Schiefermeier, Warnecke, Huber, Villunger (bib21) 2008; 29 Heyman, Mangelsdorf, Dyck, Stein, Eichele, Evans, Thaller (bib23) 1992; 68 Hermann-Kleiter, Meisel, Fresser, Thuille, Müller, Roth, Katopodis, Baier (bib22) 2012; 39 Kanehisa, Furumichi, Tanabe, Sato, Morishima (bib31) 2017; 45 Esaki, Sayano, Sonoda, Akagi, Suzuki, Ogawa, Okamoto, Yoshikawa, Hirabayashi, Furuya (bib10) 2015; 290 Palanker, Necakov, Sampson, Ni, Hu, Thummel, Krause (bib59) 2006; 133 Sanjana, Shalem, Zhang (bib76) 2014; 11 Urs, Dammer, Sewer (bib97) 2006; 147 Saied, Arenz (bib11) 2020 Huh, Leung, Huang, Ryan, Krout, Malapaka, Chow, Manel, Ciofani, Kim (bib25) 2011; 472 Wang, Gearhart, Lee, Kumar, Ramazanov, Zhang, Hernandez, Lu, Neuenkirchen, Deng (bib101) 2018; 22 Wang, Nakayama, Pitulescu, Schmidt, Bochenek, Sakakibara, Adams, Davy, Deutsch, Lüthi (bib100) 2010; 465 Maurange, Cheng, Gould (bib46) 2008; 133 Srinivasan, Oliver (bib87) 2011; 25 Le Guével, Oger, Martinez-Jimenez, Bizot, Gheeraert, Firmin, Ploton, Kretova, Palierne, Staels (bib34) 2017; 12 Folch, Lees, Sloane Stanley (bib12) 1957; 226 Renier, Wu, Simon, Yang, Ariel, Tessier-Lavigne (bib69) 2014; 159 Levin, Sturzenbecker, Kazmer, Bosakowski, Huselton, Allenby, Speck, Kratzeisen, Rosenberger, Lovey, Grippo (bib37) 1992; 355 Lifton, Dluhy, Powers, Rich, Cook, Ulick, Lalouel (bib40) 1992; 355 Osafune, Caron, Borowiak, Martinez, Fitz-Gerald, Sato, Cowan, Chien, Melton (bib57) 2008; 26 Lin, Chen, Qin, Hong, Tsai, Tsai (bib41) 2010; 120 Pipaón (10.1016/j.devcel.2021.10.018_bib65) 1999; 19 Qiu (10.1016/j.devcel.2021.10.018_bib67) 1994; 91 Kanai (10.1016/j.devcel.2021.10.018_bib29) 2005; 8 Palanker (10.1016/j.devcel.2021.10.018_bib59) 2006; 133 Tang (10.1016/j.devcel.2021.10.018_bib92) 2010; 137 Eppig (10.1016/j.devcel.2021.10.018_bib9) 2017; 58 Huh (10.1016/j.devcel.2021.10.018_bib25) 2011; 472 Petkovich (10.1016/j.devcel.2021.10.018_bib64) 1987; 330 Renier (10.1016/j.devcel.2021.10.018_bib69) 2014; 159 Uhlén (10.1016/j.devcel.2021.10.018_bib95) 2015; 347 Kawamata (10.1016/j.devcel.2021.10.018_bib32) 2003; 278 Walker (10.1016/j.devcel.2021.10.018_bib99) 2011; 147 Molina (10.1016/j.devcel.2021.10.018_bib52) 2001; 109 Saied (10.1016/j.devcel.2021.10.018_bib73) 2021; 22 Maurange (10.1016/j.devcel.2021.10.018_bib46) 2008; 133 Alecu (10.1016/j.devcel.2021.10.018_bib2) 2017; 58 Luecken (10.1016/j.devcel.2021.10.018_bib44) 2019; 15 Srinivasan (10.1016/j.devcel.2021.10.018_bib85) 2007; 21 Heyman (10.1016/j.devcel.2021.10.018_bib23) 1992; 68 Penno (10.1016/j.devcel.2021.10.018_bib61) 2010; 285 Santori (10.1016/j.devcel.2021.10.018_bib77) 2015; 21 Osafune (10.1016/j.devcel.2021.10.018_bib57) 2008; 26 Hermann-Kleiter (10.1016/j.devcel.2021.10.018_bib21) 2008; 29 Bazigou (10.1016/j.devcel.2021.10.018_bib3) 2011; 121 Shalem (10.1016/j.devcel.2021.10.018_bib82) 2014; 343 Wang (10.1016/j.devcel.2021.10.018_bib102) 2012; 10 Esaki (10.1016/j.devcel.2021.10.018_bib10) 2015; 290 Burkhardt (10.1016/j.devcel.2021.10.018_bib5) 2019 Rotthier (10.1016/j.devcel.2021.10.018_bib71) 2010; 87 Starkey (10.1016/j.devcel.2021.10.018_bib88) 2018; 159 Qiu (10.1016/j.devcel.2021.10.018_bib68) 1997; 11 Urs (10.1016/j.devcel.2021.10.018_bib97) 2006; 147 Wang (10.1016/j.devcel.2021.10.018_bib100) 2010; 465 Fu (10.1016/j.devcel.2021.10.018_bib13) 2019; 176 Makishima (10.1016/j.devcel.2021.10.018_bib45) 1999; 284 Wang (10.1016/j.devcel.2021.10.018_bib101) 2018; 22 Al Turki (10.1016/j.devcel.2021.10.018_bib1) 2014; 94 Garofalo (10.1016/j.devcel.2021.10.018_bib17) 2011; 121 Jonk (10.1016/j.devcel.2021.10.018_bib27) 1994; 47 Sasaki (10.1016/j.devcel.2021.10.018_bib78) 2009; 96 Miyake (10.1016/j.devcel.2021.10.018_bib50) 1995; 211 Tsai (10.1016/j.devcel.2021.10.018_bib94) 1997; 18 Steiner (10.1016/j.devcel.2021.10.018_bib90) 2016; 57 Burridge (10.1016/j.devcel.2021.10.018_bib6) 2014; 11 Parks (10.1016/j.devcel.2021.10.018_bib60) 1999; 284 Wolf (10.1016/j.devcel.2021.10.018_bib104) 2018; 19 Tao (10.1016/j.devcel.2021.10.018_bib93) 2020; 9 Yamaguchi (10.1016/j.devcel.2021.10.018_bib106) 2004; 266 Petersen (10.1016/j.devcel.2021.10.018_bib63) 2011; 31 Schwach (10.1016/j.devcel.2021.10.018_bib80) 2017; 9 Le Guével (10.1016/j.devcel.2021.10.018_bib34) 2017; 12 Lifton (10.1016/j.devcel.2021.10.018_bib40) 1992; 355 Lian (10.1016/j.devcel.2021.10.018_bib39) 2013; 8 Hermann-Kleiter (10.1016/j.devcel.2021.10.018_bib22) 2012; 39 Sanjana (10.1016/j.devcel.2021.10.018_bib76) 2014; 11 Moon (10.1016/j.devcel.2021.10.018_bib54) 2019; 37 Eichler (10.1016/j.devcel.2021.10.018_bib8) 2009; 29 Saito (10.1016/j.devcel.2021.10.018_bib75) 2012; 3 Janowski (10.1016/j.devcel.2021.10.018_bib26) 1996; 383 Li (10.1016/j.devcel.2021.10.018_bib38) 2009; 284 Takamoto (10.1016/j.devcel.2021.10.018_bib91) 2005; 132 Saied (10.1016/j.devcel.2021.10.018_bib11) 2020 Gauchat (10.1016/j.devcel.2021.10.018_bib18) 2004; 275 Lone (10.1016/j.devcel.2021.10.018_bib43) 2020; 117 Othman (10.1016/j.devcel.2021.10.018_bib58) 2015; 3 Zelhof (10.1016/j.devcel.2021.10.018_bib108) 1995; 15 Shan (10.1016/j.devcel.2021.10.018_bib83) 2008; 322 Uhlen (10.1016/j.devcel.2021.10.018_bib96) 2010; 28 Wu (10.1016/j.devcel.2021.10.018_bib105) 2013; 25 Merrill (10.1016/j.devcel.2021.10.018_bib48) 1988; 27 Montemayor (10.1016/j.devcel.2021.10.018_bib53) 2010; 5 Lo (10.1016/j.devcel.2021.10.018_bib42) 2004; 332 Smith (10.1016/j.devcel.2021.10.018_bib84) 2006; 78 Wang (10.1016/j.devcel.2021.10.018_bib103) 2019; 66 Pereira (10.1016/j.devcel.2021.10.018_bib62) 1999; 13 Lee (10.1016/j.devcel.2021.10.018_bib35) 2012; 287 Russo (10.1016/j.devcel.2021.10.018_bib72) 2013; 288 Mlodzik (10.1016/j.devcel.2021.10.018_bib51) 1990; 60 Fyrst (10.1016/j.devcel.2021.10.018_bib14) 2004; 45 Gantner (10.1016/j.devcel.2021.10.018_bib16) 2019; 381 Bosch (10.1016/j.devcel.2021.10.018_bib4) 2014; 94 Churko (10.1016/j.devcel.2021.10.018_bib7) 2018; 9 Merrill (10.1016/j.devcel.2021.10.018_bib47) 2011; 111 Mettler (10.1016/j.devcel.2021.10.018_bib49) 2006; 133 Hornemann (10.1016/j.devcel.2021.10.018_bib24) 2009; 284 Mwinyi (10.1016/j.devcel.2021.10.018_bib55) 2017; 12 Giguere (10.1016/j.devcel.2021.10.018_bib19) 1987; 330 Srinivasan (10.1016/j.devcel.2021.10.018_bib86) 2010; 24 Fyrst (10.1016/j.devcel.2021.10.018_bib15) 2008; 49 Kanatani (10.1016/j.devcel.2021.10.018_bib30) 2015; 112 Kanehisa (10.1016/j.devcel.2021.10.018_bib31) 2017; 45 van Westen (10.1016/j.devcel.2021.10.018_bib98) 2014; 10 Shakoury-Elizeh (10.1016/j.devcel.2021.10.018_bib81) 2010; 285 Jordan-Williams (10.1016/j.devcel.2021.10.018_bib28) 2014; 12 Hanada (10.1016/j.devcel.2021.10.018_bib20) 1992; 267 Saied (10.1016/j.devcel.2021.10.018_bib74) 2018; 26 Folch (10.1016/j.devcel.2021.10.018_bib12) 1957; 226 Lin (10.1016/j.devcel.2021.10.018_bib41) 2010; 120 Sayin (10.1016/j.devcel.2021.10.018_bib79) 2013; 17 Levin (10.1016/j.devcel.2021.10.018_bib37) 1992; 355 Srinivasan (10.1016/j.devcel.2021.10.018_bib87) 2011; 25 Kruse (10.1016/j.devcel.2021.10.018_bib33) 2008; 6 Ponzielli (10.1016/j.devcel.2021.10.018_bib66) 2002; 129 Narayanaswamy (10.1016/j.devcel.2021.10.018_bib56) 2014; 86 Revankar (10.1016/j.devcel.2021.10.018_bib70) 2005; 307 Stehling (10.1016/j.devcel.2021.10.018_bib89) 2013; 18 Lee (10.1016/j.devcel.2021.10.018_bib36) 2012; 16 You (10.1016/j.devcel.2021.10.018_bib107) 2005; 435 |
| References_xml | – volume: 11 start-page: 855 year: 2014 end-page: 860 ident: bib6 article-title: Chemically defined generation of human cardiomyocytes publication-title: Nat. Methods contributor: fullname: Mordwinkin – volume: 24 start-page: 696 year: 2010 end-page: 707 ident: bib86 article-title: The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells publication-title: Genes Dev. contributor: fullname: Oliver – volume: 176 start-page: 1098 year: 2019 end-page: 1112.e18 ident: bib13 article-title: FXR regulates intestinal cancer stem cell proliferation publication-title: Cell contributor: fullname: Liu – volume: 12 start-page: e0175776 year: 2017 ident: bib55 article-title: Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus publication-title: PLoS One contributor: fullname: Hornemann – volume: 330 start-page: 444 year: 1987 end-page: 450 ident: bib64 article-title: A human retinoic acid receptor which belongs to the family of nuclear receptors publication-title: Nature contributor: fullname: Chambon – volume: 94 start-page: 574 year: 2014 end-page: 585 ident: bib1 article-title: Rare variants in NR2F2 cause congenital heart defects in humans publication-title: Am. J. Hum. Genet. contributor: fullname: Arndt – volume: 381 start-page: 1422 year: 2019 end-page: 1433 ident: bib16 article-title: Serine and lipid metabolism in macular disease and peripheral neuropathy publication-title: N. Engl. J. Med. contributor: fullname: Heeren – volume: 25 start-page: 2187 year: 2011 end-page: 2197 ident: bib87 article-title: Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves publication-title: Genes Dev. contributor: fullname: Oliver – volume: 307 start-page: 1625 year: 2005 end-page: 1630 ident: bib70 article-title: A transmembrane intracellular estrogen receptor mediates rapid cell signaling publication-title: Science contributor: fullname: Prossnitz – volume: 3 start-page: 1262 year: 2012 ident: bib75 article-title: Luminescent proteins for high-speed single-cell and whole-body imaging publication-title: Nat. Commun. contributor: fullname: Nagai – volume: 15 start-page: e8746 year: 2019 ident: bib44 article-title: Current best practices in single-cell RNA-seq analysis: a tutorial publication-title: Mol. Syst. Biol. contributor: fullname: Theis – volume: 11 start-page: 783 year: 2014 end-page: 784 ident: bib76 article-title: Improved vectors and genome-wide libraries for CRISPR screening publication-title: Nat. Methods contributor: fullname: Zhang – volume: 68 start-page: 397 year: 1992 end-page: 406 ident: bib23 article-title: 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor publication-title: Cell contributor: fullname: Thaller – volume: 3 start-page: e000073 year: 2015 ident: bib58 article-title: Plasma 1-deoxysphingolipids are predictive biomarkers for type 2 diabetes mellitus publication-title: BMJ Open Diabetes Res. Care contributor: fullname: Hornemann – volume: 5 start-page: e8910 year: 2010 ident: bib53 article-title: Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI publication-title: PLoS One contributor: fullname: Pereira – volume: 86 start-page: 3043 year: 2014 end-page: 3047 ident: bib56 article-title: Lipidomic "deep profiling": an enhanced workflow to reveal new molecular species of signaling lipids publication-title: Anal. Chem. contributor: fullname: Wenk – volume: 8 start-page: 203 year: 2005 end-page: 213 ident: bib29 article-title: Seven-up controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts publication-title: Dev. Cell contributor: fullname: Hiromi – volume: 12 start-page: 654 year: 2017 end-page: 663 ident: bib34 article-title: Inactivation of the nuclear orphan receptor COUP-TFII by small chemicals publication-title: ACS Chem. Biol. contributor: fullname: Staels – volume: 25 start-page: 417 year: 2013 end-page: 426 ident: bib105 article-title: Atrial identity is determined by a COUP-TFII regulatory network publication-title: Dev. Cell contributor: fullname: Tsai – volume: 91 start-page: 4451 year: 1994 end-page: 4455 ident: bib67 article-title: Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Tsai – volume: 31 start-page: 15362 year: 2011 end-page: 15375 ident: bib63 article-title: A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans publication-title: J. Neurosci. contributor: fullname: Miller – volume: 332 start-page: 153 year: 2004 end-page: 159 ident: bib42 article-title: Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery publication-title: Anal. Biochem. contributor: fullname: Ellestad – volume: 94 start-page: 303 year: 2014 end-page: 309 ident: bib4 article-title: NR2F1 mutations cause optic atrophy with intellectual disability publication-title: Am. J. Hum. Genet. contributor: fullname: Pfundt – volume: 288 start-page: 13397 year: 2013 end-page: 13409 ident: bib72 article-title: Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties publication-title: J. Biol. Chem. contributor: fullname: Cowart – volume: 285 start-page: 11178 year: 2010 end-page: 11187 ident: bib61 article-title: Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids publication-title: J. Biol. Chem. contributor: fullname: Brown – volume: 10 start-page: 440 year: 2012 end-page: 454 ident: bib102 article-title: Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells publication-title: Cell Stem Cell contributor: fullname: Ivanova – volume: 275 start-page: 104 year: 2004 end-page: 123 ident: bib18 article-title: The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates publication-title: Dev. Biol. contributor: fullname: Galliot – volume: 11 start-page: 1925 year: 1997 end-page: 1937 ident: bib68 article-title: Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization publication-title: Genes Dev. contributor: fullname: Tsai – volume: 22 start-page: 235 year: 2018 end-page: 251.e9 ident: bib101 article-title: A non-canonical BCOR-PRC1.1 complex represses differentiation programs in human ESCs publication-title: Cell Stem Cell contributor: fullname: Deng – volume: 211 start-page: 396 year: 1995 end-page: 403 ident: bib50 article-title: Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Kawasaki – volume: 27 start-page: 340 year: 1988 end-page: 345 ident: bib48 article-title: Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway publication-title: Biochemistry contributor: fullname: Mullins – volume: 19 start-page: 2734 year: 1999 end-page: 2745 ident: bib65 article-title: COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site publication-title: Mol. Cell. Biol. contributor: fullname: Tsai – volume: 285 start-page: 14823 year: 2010 end-page: 14833 ident: bib81 article-title: Metabolic response to iron deficiency in Saccharomyces cerevisiae publication-title: J. Biol. Chem. contributor: fullname: Philpott – volume: 10 start-page: e1003559 year: 2014 ident: bib98 article-title: Chemical, target, and bioactive properties of allosteric modulation publication-title: PLoS Comput. Biol. contributor: fullname: Overington – volume: 60 start-page: 211 year: 1990 end-page: 224 ident: bib51 article-title: The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates publication-title: Cell contributor: fullname: Rubin – volume: 66 start-page: 23 year: 2019 end-page: 27 ident: bib103 article-title: Combining CRISPR/Cas9-mediated knockout with genetic complementation for in-depth mechanistic studies in human ES cells publication-title: BioTechniques contributor: fullname: Ivanova – volume: 29 start-page: 14646 year: 2009 end-page: 14651 ident: bib8 article-title: Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1 publication-title: J. Neurosci. contributor: fullname: Kini – volume: 355 start-page: 262 year: 1992 end-page: 265 ident: bib40 article-title: A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension publication-title: Nature contributor: fullname: Lalouel – volume: 18 start-page: 229 year: 1997 end-page: 240 ident: bib94 article-title: Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age publication-title: Endocr. Rev. contributor: fullname: Tsai – volume: 111 start-page: 6387 year: 2011 end-page: 6422 ident: bib47 article-title: Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics publication-title: Chem. Rev. contributor: fullname: Merrill – volume: 347 start-page: 1260419 year: 2015 ident: bib95 article-title: Proteomics. Tissue-based map of the human proteome publication-title: Science contributor: fullname: Asplund – year: 2020 ident: bib11 article-title: Synthesis and characterization of novel atypical sphingoid bases publication-title: ChemRxiv contributor: fullname: Arenz – volume: 435 start-page: 98 year: 2005 end-page: 104 ident: bib107 article-title: Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity publication-title: Nature contributor: fullname: Tsai – volume: 343 start-page: 84 year: 2014 end-page: 87 ident: bib82 article-title: Genome-scale CRISPR-Cas9 knockout screening in human cells publication-title: Science contributor: fullname: Zhang – volume: 96 start-page: 2727 year: 2009 end-page: 2733 ident: bib78 article-title: pH dependence of sphingosine aggregation publication-title: Biophys. J. contributor: fullname: White – volume: 284 start-page: 27010 year: 2009 end-page: 27019 ident: bib38 article-title: Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels publication-title: J. Biol. Chem. contributor: fullname: Jiang – volume: 45 start-page: 54 year: 2004 end-page: 62 ident: bib14 article-title: Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster publication-title: J. Lipid Res. contributor: fullname: Saba – volume: 121 start-page: 4735 year: 2011 end-page: 4745 ident: bib17 article-title: Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1 publication-title: J. Clin. Invest. contributor: fullname: Eichler – volume: 28 start-page: 1248 year: 2010 end-page: 1250 ident: bib96 article-title: Towards a knowledge-based Human Protein Atlas publication-title: Nat. Biotechnol. contributor: fullname: Hober – volume: 78 start-page: 779 year: 2006 end-page: 787 ident: bib84 article-title: XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification publication-title: Anal. Chem. contributor: fullname: Siuzdak – volume: 19 start-page: 15 year: 2018 ident: bib104 article-title: SCANPY: large-scale single-cell gene expression data analysis publication-title: Genome Biol. contributor: fullname: Theis – year: 2019 ident: bib5 article-title: Quantifying the effect of experimental perturbations in single-cell RNA-sequencing data using graph signal processing publication-title: bioRxiv contributor: fullname: Krishnaswamy – volume: 383 start-page: 728 year: 1996 end-page: 731 ident: bib26 article-title: An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha publication-title: Nature contributor: fullname: Mangelsdorf – volume: 39 start-page: 428 year: 2012 end-page: 440 ident: bib22 article-title: Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter publication-title: J. Autoimmun. contributor: fullname: Baier – volume: 117 start-page: 15591 year: 2020 end-page: 15598 ident: bib43 article-title: Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Hornemann – volume: 18 start-page: 187 year: 2013 end-page: 198 ident: bib89 article-title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins publication-title: Cell Metab. contributor: fullname: Lill – volume: 58 start-page: 17 year: 2017 end-page: 41 ident: bib9 article-title: Mouse genome informatics (MGI) resource: genetic, genomic, and biological KnowledgeBase for the laboratory mouse publication-title: ILAR J contributor: fullname: Eppig – volume: 26 start-page: 313 year: 2008 end-page: 315 ident: bib57 article-title: Marked differences in differentiation propensity among human embryonic stem cell lines publication-title: Nat. Biotechnol. contributor: fullname: Melton – volume: 159 start-page: 1972 year: 2018 end-page: 1981 ident: bib88 article-title: 27-Hydroxycholesterol is an estrogen receptor beta-selective negative allosteric modifier of 17beta-estradiol binding publication-title: Endocrinology contributor: fullname: Lubahn – volume: 330 start-page: 624 year: 1987 end-page: 629 ident: bib19 article-title: Identification of a receptor for the morphogen retinoic acid publication-title: Nature contributor: fullname: Evans – volume: 226 start-page: 497 year: 1957 end-page: 509 ident: bib12 article-title: A simple method for the isolation and purification of total lipides from animal tissues publication-title: J. Biol. Chem. contributor: fullname: Sloane Stanley – volume: 8 start-page: 162 year: 2013 end-page: 175 ident: bib39 article-title: Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions publication-title: Nat. Protoc. contributor: fullname: Palecek – volume: 47 start-page: 81 year: 1994 end-page: 97 ident: bib27 article-title: Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors publication-title: Mech. Dev. contributor: fullname: Kruijer – volume: 132 start-page: 2179 year: 2005 end-page: 2189 ident: bib91 article-title: COUP-TFII is essential for radial and anteroposterior patterning of the stomach publication-title: Development contributor: fullname: Tsai – volume: 284 start-page: 26322 year: 2009 end-page: 26330 ident: bib24 article-title: The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases publication-title: J. Biol. Chem. contributor: fullname: von Eckardstein – volume: 133 start-page: 429 year: 2006 end-page: 437 ident: bib49 article-title: Timing of identity: spatiotemporal regulation of hunchback in neuroblast lineages of Drosophila by seven-up and Prospero publication-title: Development contributor: fullname: Urban – volume: 465 start-page: 483 year: 2010 end-page: 486 ident: bib100 article-title: Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis publication-title: Nature contributor: fullname: Lüthi – volume: 16 start-page: 90 year: 2012 end-page: 96 ident: bib36 article-title: Sphingolipid signaling mediates iron toxicity publication-title: Cell Metab. contributor: fullname: Chanfreau – volume: 120 start-page: 1694 year: 2010 end-page: 1707 ident: bib41 article-title: Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development publication-title: J. Clin. Invest. contributor: fullname: Tsai – volume: 13 start-page: 1037 year: 1999 end-page: 1049 ident: bib62 article-title: The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development publication-title: Genes Dev. contributor: fullname: Tsai – volume: 133 start-page: 891 year: 2008 end-page: 902 ident: bib46 article-title: Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila publication-title: Cell contributor: fullname: Gould – volume: 58 start-page: 60 year: 2017 end-page: 71 ident: bib2 article-title: Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway publication-title: J. Lipid Res. contributor: fullname: Hornemann – volume: 121 start-page: 2984 year: 2011 end-page: 2992 ident: bib3 article-title: Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice publication-title: J. Clin. Invest. contributor: fullname: Makinen – volume: 26 start-page: 4047 year: 2018 end-page: 4057 ident: bib74 article-title: Synthesis and characterization of some atypical sphingoid bases publication-title: Bioorg. Med. Chem. contributor: fullname: Arenz – volume: 15 start-page: 6736 year: 1995 end-page: 6745 ident: bib108 article-title: Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo publication-title: Mol. Cell. Biol. contributor: fullname: McKeown – volume: 129 start-page: 4509 year: 2002 end-page: 4521 ident: bib66 article-title: Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the bithorax Complex genes and hedgehog signaling publication-title: Development contributor: fullname: Sémériva – volume: 37 start-page: 1482 year: 2019 end-page: 1492 ident: bib54 article-title: Visualizing structure and transitions in high-dimensional biological data publication-title: Nat. Biotechnol. contributor: fullname: Coifman – volume: 9 start-page: 1765 year: 2017 end-page: 1779 ident: bib80 article-title: A COUP-TFII human embryonic stem cell reporter line to identify and select atrial cardiomyocytes publication-title: Stem Cell Rep. contributor: fullname: Passier – volume: 109 start-page: 51 year: 2001 end-page: 59 ident: bib52 article-title: Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells publication-title: Mech. Dev. contributor: fullname: Cripps – volume: 21 start-page: 2422 year: 2007 end-page: 2432 ident: bib85 article-title: Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature publication-title: Genes Dev. contributor: fullname: Oliver – volume: 278 start-page: 9435 year: 2003 end-page: 9440 ident: bib32 article-title: A G protein-coupled receptor responsive to bile acids publication-title: J. Biol. Chem. contributor: fullname: Shintani – volume: 267 start-page: 23527 year: 1992 end-page: 23533 ident: bib20 article-title: Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids publication-title: J. Biol. Chem. contributor: fullname: Akamatsu – volume: 12 start-page: 144 year: 2014 end-page: 149 ident: bib28 article-title: Culturing purifies murine lymph node lymphatic endothelium publication-title: Lymphat. Res. Biol. contributor: fullname: Ruddell – volume: 284 start-page: 1365 year: 1999 end-page: 1368 ident: bib60 article-title: Bile acids: natural ligands for an orphan nuclear receptor publication-title: Science contributor: fullname: Lehmann – volume: 22 start-page: 8171 year: 2021 ident: bib73 article-title: Stereoselective synthesis of novel sphingoid bases utilized for exploring the secrets of sphinx publication-title: Int. J. Mol. Sci. contributor: fullname: Arenz – volume: 147 start-page: 5249 year: 2006 end-page: 5258 ident: bib97 article-title: Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1 publication-title: Endocrinology contributor: fullname: Sewer – volume: 472 start-page: 486 year: 2011 end-page: 490 ident: bib25 article-title: Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity publication-title: Nature contributor: fullname: Kim – volume: 45 start-page: D353 year: 2017 end-page: D361 ident: bib31 article-title: KEGG: new perspectives on genomes, pathways, diseases and drugs publication-title: Nucleic Acids Res contributor: fullname: Morishima – volume: 284 start-page: 1362 year: 1999 end-page: 1365 ident: bib45 article-title: Identification of a nuclear receptor for bile acids publication-title: Science contributor: fullname: Shan – volume: 49 start-page: 597 year: 2008 end-page: 606 ident: bib15 article-title: Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes publication-title: J. Lipid Res. contributor: fullname: Saba – volume: 290 start-page: 14595 year: 2015 end-page: 14609 ident: bib10 article-title: L-serine deficiency elicits intracellular accumulation of cytotoxic deoxysphingolipids and lipid body formation publication-title: J. Biol. Chem. contributor: fullname: Furuya – volume: 9 start-page: 2606 year: 2020 ident: bib93 article-title: Nuclear hormone receptors and their ligands: metabolites in control of transcription publication-title: Cells contributor: fullname: Santori – volume: 17 start-page: 225 year: 2013 end-page: 235 ident: bib79 article-title: Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist publication-title: Cell Metab. contributor: fullname: Bäckhed – volume: 159 start-page: 896 year: 2014 end-page: 910 ident: bib69 article-title: iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging publication-title: Cell contributor: fullname: Tessier-Lavigne – volume: 147 start-page: 840 year: 2011 end-page: 852 ident: bib99 article-title: A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans publication-title: Cell contributor: fullname: Niebergall – volume: 322 start-page: 11 year: 2008 end-page: 20 ident: bib83 article-title: Copulation in C. elegans males requires a nuclear hormone receptor publication-title: Dev. Biol. contributor: fullname: Walthall – volume: 9 start-page: 4906 year: 2018 ident: bib7 article-title: Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis publication-title: Nat. Commun. contributor: fullname: Chetal – volume: 137 start-page: 725 year: 2010 end-page: 734 ident: bib92 article-title: COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis publication-title: Development contributor: fullname: Tsai – volume: 29 start-page: 205 year: 2008 end-page: 216 ident: bib21 article-title: The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity publication-title: Immunity contributor: fullname: Villunger – volume: 355 start-page: 359 year: 1992 end-page: 361 ident: bib37 article-title: 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha publication-title: Nature contributor: fullname: Grippo – volume: 287 start-page: 18429 year: 2012 end-page: 18439 ident: bib35 article-title: Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction publication-title: J. Biol. Chem. contributor: fullname: Lee – volume: 6 start-page: e227 year: 2008 ident: bib33 article-title: Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor publication-title: PLoS Biol contributor: fullname: Xu – volume: 21 start-page: 286 year: 2015 end-page: 298 ident: bib77 article-title: Identification of natural RORgamma ligands that regulate the development of lymphoid cells publication-title: Cell Metab. contributor: fullname: Rosales – volume: 57 start-page: 1194 year: 2016 end-page: 1203 ident: bib90 article-title: Elucidating the chemical structure of native 1-deoxysphingosine publication-title: J. Lipid Res. contributor: fullname: Hornemann – volume: 133 start-page: 3549 year: 2006 end-page: 3562 ident: bib59 article-title: Dynamic regulation of Drosophila nuclear receptor activity in vivo publication-title: Development contributor: fullname: Krause – volume: 87 start-page: 513 year: 2010 end-page: 522 ident: bib71 article-title: Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I publication-title: Am. J. Hum. Genet. contributor: fullname: Schlotter-Weigel – volume: 266 start-page: 238 year: 2004 end-page: 251 ident: bib106 article-title: The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes publication-title: Dev. Biol. contributor: fullname: Tsai – volume: 112 start-page: E4985 year: 2015 end-page: E4994 ident: bib30 article-title: The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Kusuzawa – volume: 226 start-page: 497 year: 1957 ident: 10.1016/j.devcel.2021.10.018_bib12 article-title: A simple method for the isolation and purification of total lipides from animal tissues publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)64849-5 contributor: fullname: Folch – volume: 45 start-page: 54 year: 2004 ident: 10.1016/j.devcel.2021.10.018_bib14 article-title: Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster publication-title: J. Lipid Res. doi: 10.1194/jlr.M300005-JLR200 contributor: fullname: Fyrst – year: 2020 ident: 10.1016/j.devcel.2021.10.018_bib11 article-title: Synthesis and characterization of novel atypical sphingoid bases publication-title: ChemRxiv contributor: fullname: Saied – volume: 132 start-page: 2179 year: 2005 ident: 10.1016/j.devcel.2021.10.018_bib91 article-title: COUP-TFII is essential for radial and anteroposterior patterning of the stomach publication-title: Development doi: 10.1242/dev.01808 contributor: fullname: Takamoto – volume: 322 start-page: 11 year: 2008 ident: 10.1016/j.devcel.2021.10.018_bib83 article-title: Copulation in C. elegans males requires a nuclear hormone receptor publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2008.06.034 contributor: fullname: Shan – volume: 18 start-page: 229 year: 1997 ident: 10.1016/j.devcel.2021.10.018_bib94 article-title: Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age publication-title: Endocr. Rev. contributor: fullname: Tsai – volume: 5 start-page: e8910 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib53 article-title: Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI publication-title: PLoS One doi: 10.1371/journal.pone.0008910 contributor: fullname: Montemayor – volume: 11 start-page: 783 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib76 article-title: Improved vectors and genome-wide libraries for CRISPR screening publication-title: Nat. Methods doi: 10.1038/nmeth.3047 contributor: fullname: Sanjana – volume: 15 start-page: 6736 year: 1995 ident: 10.1016/j.devcel.2021.10.018_bib108 article-title: Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.15.12.6736 contributor: fullname: Zelhof – volume: 57 start-page: 1194 year: 2016 ident: 10.1016/j.devcel.2021.10.018_bib90 article-title: Elucidating the chemical structure of native 1-deoxysphingosine publication-title: J. Lipid Res. doi: 10.1194/jlr.M067033 contributor: fullname: Steiner – volume: 266 start-page: 238 year: 2004 ident: 10.1016/j.devcel.2021.10.018_bib106 article-title: The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2003.10.038 contributor: fullname: Yamaguchi – volume: 11 start-page: 1925 year: 1997 ident: 10.1016/j.devcel.2021.10.018_bib68 article-title: Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization publication-title: Genes Dev. doi: 10.1101/gad.11.15.1925 contributor: fullname: Qiu – volume: 25 start-page: 2187 year: 2011 ident: 10.1016/j.devcel.2021.10.018_bib87 article-title: Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves publication-title: Genes Dev. doi: 10.1101/gad.16974811 contributor: fullname: Srinivasan – volume: 29 start-page: 205 year: 2008 ident: 10.1016/j.devcel.2021.10.018_bib21 article-title: The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity publication-title: Immunity doi: 10.1016/j.immuni.2008.06.008 contributor: fullname: Hermann-Kleiter – volume: 58 start-page: 60 year: 2017 ident: 10.1016/j.devcel.2021.10.018_bib2 article-title: Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway publication-title: J. Lipid Res. doi: 10.1194/jlr.M072421 contributor: fullname: Alecu – volume: 8 start-page: 203 year: 2005 ident: 10.1016/j.devcel.2021.10.018_bib29 article-title: Seven-up controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts publication-title: Dev. Cell doi: 10.1016/j.devcel.2004.12.014 contributor: fullname: Kanai – volume: 285 start-page: 14823 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib81 article-title: Metabolic response to iron deficiency in Saccharomyces cerevisiae publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.091710 contributor: fullname: Shakoury-Elizeh – volume: 29 start-page: 14646 year: 2009 ident: 10.1016/j.devcel.2021.10.018_bib8 article-title: Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2536-09.2009 contributor: fullname: Eichler – volume: 332 start-page: 153 year: 2004 ident: 10.1016/j.devcel.2021.10.018_bib42 article-title: Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery publication-title: Anal. Biochem. doi: 10.1016/j.ab.2004.04.031 contributor: fullname: Lo – volume: 78 start-page: 779 year: 2006 ident: 10.1016/j.devcel.2021.10.018_bib84 article-title: XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification publication-title: Anal. Chem. doi: 10.1021/ac051437y contributor: fullname: Smith – volume: 47 start-page: 81 year: 1994 ident: 10.1016/j.devcel.2021.10.018_bib27 article-title: Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors publication-title: Mech. Dev. doi: 10.1016/0925-4773(94)90098-1 contributor: fullname: Jonk – volume: 49 start-page: 597 year: 2008 ident: 10.1016/j.devcel.2021.10.018_bib15 article-title: Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes publication-title: J. Lipid Res. doi: 10.1194/jlr.M700414-JLR200 contributor: fullname: Fyrst – volume: 159 start-page: 1972 year: 2018 ident: 10.1016/j.devcel.2021.10.018_bib88 article-title: 27-Hydroxycholesterol is an estrogen receptor beta-selective negative allosteric modifier of 17beta-estradiol binding publication-title: Endocrinology doi: 10.1210/en.2018-00081 contributor: fullname: Starkey – volume: 87 start-page: 513 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib71 article-title: Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2010.09.010 contributor: fullname: Rotthier – volume: 288 start-page: 13397 year: 2013 ident: 10.1016/j.devcel.2021.10.018_bib72 article-title: Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.428185 contributor: fullname: Russo – volume: 112 start-page: E4985 year: 2015 ident: 10.1016/j.devcel.2021.10.018_bib30 article-title: The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1420701112 contributor: fullname: Kanatani – volume: 355 start-page: 359 year: 1992 ident: 10.1016/j.devcel.2021.10.018_bib37 article-title: 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha publication-title: Nature doi: 10.1038/355359a0 contributor: fullname: Levin – volume: 383 start-page: 728 year: 1996 ident: 10.1016/j.devcel.2021.10.018_bib26 article-title: An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha publication-title: Nature doi: 10.1038/383728a0 contributor: fullname: Janowski – volume: 96 start-page: 2727 year: 2009 ident: 10.1016/j.devcel.2021.10.018_bib78 article-title: pH dependence of sphingosine aggregation publication-title: Biophys. J. doi: 10.1016/j.bpj.2008.12.3926 contributor: fullname: Sasaki – volume: 10 start-page: e1003559 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib98 article-title: Chemical, target, and bioactive properties of allosteric modulation publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1003559 contributor: fullname: van Westen – volume: 435 start-page: 98 year: 2005 ident: 10.1016/j.devcel.2021.10.018_bib107 article-title: Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity publication-title: Nature doi: 10.1038/nature03511 contributor: fullname: You – volume: 16 start-page: 90 year: 2012 ident: 10.1016/j.devcel.2021.10.018_bib36 article-title: Sphingolipid signaling mediates iron toxicity publication-title: Cell Metab. doi: 10.1016/j.cmet.2012.06.004 contributor: fullname: Lee – volume: 60 start-page: 211 year: 1990 ident: 10.1016/j.devcel.2021.10.018_bib51 article-title: The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates publication-title: Cell doi: 10.1016/0092-8674(90)90737-Y contributor: fullname: Mlodzik – volume: 120 start-page: 1694 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib41 article-title: Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development publication-title: J. Clin. Invest. doi: 10.1172/JCI40101 contributor: fullname: Lin – volume: 26 start-page: 4047 year: 2018 ident: 10.1016/j.devcel.2021.10.018_bib74 article-title: Synthesis and characterization of some atypical sphingoid bases publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2018.06.031 contributor: fullname: Saied – volume: 68 start-page: 397 year: 1992 ident: 10.1016/j.devcel.2021.10.018_bib23 article-title: 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor publication-title: Cell doi: 10.1016/0092-8674(92)90479-V contributor: fullname: Heyman – volume: 278 start-page: 9435 year: 2003 ident: 10.1016/j.devcel.2021.10.018_bib32 article-title: A G protein-coupled receptor responsive to bile acids publication-title: J. Biol. Chem. doi: 10.1074/jbc.M209706200 contributor: fullname: Kawamata – volume: 12 start-page: 654 year: 2017 ident: 10.1016/j.devcel.2021.10.018_bib34 article-title: Inactivation of the nuclear orphan receptor COUP-TFII by small chemicals publication-title: ACS Chem. Biol. doi: 10.1021/acschembio.6b00593 contributor: fullname: Le Guével – volume: 13 start-page: 1037 year: 1999 ident: 10.1016/j.devcel.2021.10.018_bib62 article-title: The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development publication-title: Genes Dev. doi: 10.1101/gad.13.8.1037 contributor: fullname: Pereira – volume: 111 start-page: 6387 year: 2011 ident: 10.1016/j.devcel.2021.10.018_bib47 article-title: Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics publication-title: Chem. Rev. doi: 10.1021/cr2002917 contributor: fullname: Merrill – volume: 22 start-page: 235 year: 2018 ident: 10.1016/j.devcel.2021.10.018_bib101 article-title: A non-canonical BCOR-PRC1.1 complex represses differentiation programs in human ESCs publication-title: Cell Stem Cell doi: 10.1016/j.stem.2017.12.002 contributor: fullname: Wang – volume: 147 start-page: 840 year: 2011 ident: 10.1016/j.devcel.2021.10.018_bib99 article-title: A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans publication-title: Cell doi: 10.1016/j.cell.2011.09.045 contributor: fullname: Walker – volume: 6 start-page: e227 year: 2008 ident: 10.1016/j.devcel.2021.10.018_bib33 article-title: Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor publication-title: PLoS Biol doi: 10.1371/journal.pbio.0060227 contributor: fullname: Kruse – volume: 31 start-page: 15362 year: 2011 ident: 10.1016/j.devcel.2021.10.018_bib63 article-title: A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3181-11.2011 contributor: fullname: Petersen – volume: 94 start-page: 303 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib4 article-title: NR2F1 mutations cause optic atrophy with intellectual disability publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2014.01.002 contributor: fullname: Bosch – volume: 12 start-page: e0175776 year: 2017 ident: 10.1016/j.devcel.2021.10.018_bib55 article-title: Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus publication-title: PLoS One doi: 10.1371/journal.pone.0175776 contributor: fullname: Mwinyi – volume: 18 start-page: 187 year: 2013 ident: 10.1016/j.devcel.2021.10.018_bib89 article-title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.06.015 contributor: fullname: Stehling – volume: 287 start-page: 18429 year: 2012 ident: 10.1016/j.devcel.2021.10.018_bib35 article-title: Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.296947 contributor: fullname: Lee – volume: 21 start-page: 286 year: 2015 ident: 10.1016/j.devcel.2021.10.018_bib77 article-title: Identification of natural RORgamma ligands that regulate the development of lymphoid cells publication-title: Cell Metab. doi: 10.1016/j.cmet.2015.01.004 contributor: fullname: Santori – volume: 17 start-page: 225 year: 2013 ident: 10.1016/j.devcel.2021.10.018_bib79 article-title: Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.01.003 contributor: fullname: Sayin – volume: 147 start-page: 5249 year: 2006 ident: 10.1016/j.devcel.2021.10.018_bib97 article-title: Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1 publication-title: Endocrinology doi: 10.1210/en.2006-0355 contributor: fullname: Urs – volume: 12 start-page: 144 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib28 article-title: Culturing purifies murine lymph node lymphatic endothelium publication-title: Lymphat. Res. Biol. doi: 10.1089/lrb.2013.0053 contributor: fullname: Jordan-Williams – volume: 26 start-page: 313 year: 2008 ident: 10.1016/j.devcel.2021.10.018_bib57 article-title: Marked differences in differentiation propensity among human embryonic stem cell lines publication-title: Nat. Biotechnol. doi: 10.1038/nbt1383 contributor: fullname: Osafune – volume: 21 start-page: 2422 year: 2007 ident: 10.1016/j.devcel.2021.10.018_bib85 article-title: Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature publication-title: Genes Dev. doi: 10.1101/gad.1588407 contributor: fullname: Srinivasan – volume: 176 start-page: 1098 year: 2019 ident: 10.1016/j.devcel.2021.10.018_bib13 article-title: FXR regulates intestinal cancer stem cell proliferation publication-title: Cell doi: 10.1016/j.cell.2019.01.036 contributor: fullname: Fu – volume: 133 start-page: 891 year: 2008 ident: 10.1016/j.devcel.2021.10.018_bib46 article-title: Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila publication-title: Cell doi: 10.1016/j.cell.2008.03.034 contributor: fullname: Maurange – volume: 10 start-page: 440 year: 2012 ident: 10.1016/j.devcel.2021.10.018_bib102 article-title: Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2012.02.016 contributor: fullname: Wang – volume: 267 start-page: 23527 year: 1992 ident: 10.1016/j.devcel.2021.10.018_bib20 article-title: Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)35871-X contributor: fullname: Hanada – volume: 284 start-page: 26322 year: 2009 ident: 10.1016/j.devcel.2021.10.018_bib24 article-title: The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.023192 contributor: fullname: Hornemann – volume: 15 start-page: e8746 year: 2019 ident: 10.1016/j.devcel.2021.10.018_bib44 article-title: Current best practices in single-cell RNA-seq analysis: a tutorial publication-title: Mol. Syst. Biol. doi: 10.15252/msb.20188746 contributor: fullname: Luecken – volume: 19 start-page: 2734 year: 1999 ident: 10.1016/j.devcel.2021.10.018_bib65 article-title: COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.19.4.2734 contributor: fullname: Pipaón – volume: 9 start-page: 4906 year: 2018 ident: 10.1016/j.devcel.2021.10.018_bib7 article-title: Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis publication-title: Nat. Commun. doi: 10.1038/s41467-018-07333-4 contributor: fullname: Churko – volume: 290 start-page: 14595 year: 2015 ident: 10.1016/j.devcel.2021.10.018_bib10 article-title: L-serine deficiency elicits intracellular accumulation of cytotoxic deoxysphingolipids and lipid body formation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.603860 contributor: fullname: Esaki – volume: 121 start-page: 2984 year: 2011 ident: 10.1016/j.devcel.2021.10.018_bib3 article-title: Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice publication-title: J. Clin. Invest. doi: 10.1172/JCI58050 contributor: fullname: Bazigou – volume: 284 start-page: 1362 year: 1999 ident: 10.1016/j.devcel.2021.10.018_bib45 article-title: Identification of a nuclear receptor for bile acids publication-title: Science doi: 10.1126/science.284.5418.1362 contributor: fullname: Makishima – volume: 121 start-page: 4735 year: 2011 ident: 10.1016/j.devcel.2021.10.018_bib17 article-title: Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1 publication-title: J. Clin. Invest. doi: 10.1172/JCI57549 contributor: fullname: Garofalo – volume: 45 start-page: D353 year: 2017 ident: 10.1016/j.devcel.2021.10.018_bib31 article-title: KEGG: new perspectives on genomes, pathways, diseases and drugs publication-title: Nucleic Acids Res doi: 10.1093/nar/gkw1092 contributor: fullname: Kanehisa – volume: 347 start-page: 1260419 year: 2015 ident: 10.1016/j.devcel.2021.10.018_bib95 article-title: Proteomics. Tissue-based map of the human proteome publication-title: Science doi: 10.1126/science.1260419 contributor: fullname: Uhlén – volume: 109 start-page: 51 year: 2001 ident: 10.1016/j.devcel.2021.10.018_bib52 article-title: Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells publication-title: Mech. Dev. doi: 10.1016/S0925-4773(01)00509-3 contributor: fullname: Molina – volume: 137 start-page: 725 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib92 article-title: COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis publication-title: Development doi: 10.1242/dev.040568 contributor: fullname: Tang – volume: 472 start-page: 486 year: 2011 ident: 10.1016/j.devcel.2021.10.018_bib25 article-title: Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity publication-title: Nature doi: 10.1038/nature09978 contributor: fullname: Huh – volume: 19 start-page: 15 year: 2018 ident: 10.1016/j.devcel.2021.10.018_bib104 article-title: SCANPY: large-scale single-cell gene expression data analysis publication-title: Genome Biol. doi: 10.1186/s13059-017-1382-0 contributor: fullname: Wolf – volume: 129 start-page: 4509 year: 2002 ident: 10.1016/j.devcel.2021.10.018_bib66 article-title: Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the bithorax Complex genes and hedgehog signaling publication-title: Development doi: 10.1242/dev.129.19.4509 contributor: fullname: Ponzielli – volume: 22 start-page: 8171 year: 2021 ident: 10.1016/j.devcel.2021.10.018_bib73 article-title: Stereoselective synthesis of novel sphingoid bases utilized for exploring the secrets of sphinx publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22158171 contributor: fullname: Saied – volume: 284 start-page: 27010 year: 2009 ident: 10.1016/j.devcel.2021.10.018_bib38 article-title: Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.042028 contributor: fullname: Li – volume: 159 start-page: 896 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib69 article-title: iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging publication-title: Cell doi: 10.1016/j.cell.2014.10.010 contributor: fullname: Renier – volume: 211 start-page: 396 year: 1995 ident: 10.1016/j.devcel.2021.10.018_bib50 article-title: Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1995.1827 contributor: fullname: Miyake – volume: 133 start-page: 429 year: 2006 ident: 10.1016/j.devcel.2021.10.018_bib49 article-title: Timing of identity: spatiotemporal regulation of hunchback in neuroblast lineages of Drosophila by seven-up and Prospero publication-title: Development doi: 10.1242/dev.02229 contributor: fullname: Mettler – volume: 66 start-page: 23 year: 2019 ident: 10.1016/j.devcel.2021.10.018_bib103 article-title: Combining CRISPR/Cas9-mediated knockout with genetic complementation for in-depth mechanistic studies in human ES cells publication-title: BioTechniques doi: 10.2144/btn-2018-0115 contributor: fullname: Wang – volume: 465 start-page: 483 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib100 article-title: Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis publication-title: Nature doi: 10.1038/nature09002 contributor: fullname: Wang – volume: 275 start-page: 104 year: 2004 ident: 10.1016/j.devcel.2021.10.018_bib18 article-title: The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2004.07.037 contributor: fullname: Gauchat – volume: 28 start-page: 1248 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib96 article-title: Towards a knowledge-based Human Protein Atlas publication-title: Nat. Biotechnol. doi: 10.1038/nbt1210-1248 contributor: fullname: Uhlen – volume: 284 start-page: 1365 year: 1999 ident: 10.1016/j.devcel.2021.10.018_bib60 article-title: Bile acids: natural ligands for an orphan nuclear receptor publication-title: Science doi: 10.1126/science.284.5418.1365 contributor: fullname: Parks – volume: 381 start-page: 1422 year: 2019 ident: 10.1016/j.devcel.2021.10.018_bib16 article-title: Serine and lipid metabolism in macular disease and peripheral neuropathy publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1815111 contributor: fullname: Gantner – volume: 27 start-page: 340 year: 1988 ident: 10.1016/j.devcel.2021.10.018_bib48 article-title: Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway publication-title: Biochemistry doi: 10.1021/bi00401a051 contributor: fullname: Merrill – volume: 58 start-page: 17 year: 2017 ident: 10.1016/j.devcel.2021.10.018_bib9 article-title: Mouse genome informatics (MGI) resource: genetic, genomic, and biological KnowledgeBase for the laboratory mouse publication-title: ILAR J doi: 10.1093/ilar/ilx013 contributor: fullname: Eppig – volume: 8 start-page: 162 year: 2013 ident: 10.1016/j.devcel.2021.10.018_bib39 article-title: Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions publication-title: Nat. Protoc. doi: 10.1038/nprot.2012.150 contributor: fullname: Lian – volume: 330 start-page: 624 year: 1987 ident: 10.1016/j.devcel.2021.10.018_bib19 article-title: Identification of a receptor for the morphogen retinoic acid publication-title: Nature doi: 10.1038/330624a0 contributor: fullname: Giguere – volume: 11 start-page: 855 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib6 article-title: Chemically defined generation of human cardiomyocytes publication-title: Nat. Methods doi: 10.1038/nmeth.2999 contributor: fullname: Burridge – volume: 3 start-page: e000073 year: 2015 ident: 10.1016/j.devcel.2021.10.018_bib58 article-title: Plasma 1-deoxysphingolipids are predictive biomarkers for type 2 diabetes mellitus publication-title: BMJ Open Diabetes Res. Care doi: 10.1136/bmjdrc-2014-000073 contributor: fullname: Othman – volume: 117 start-page: 15591 year: 2020 ident: 10.1016/j.devcel.2021.10.018_bib43 article-title: Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2002391117 contributor: fullname: Lone – volume: 94 start-page: 574 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib1 article-title: Rare variants in NR2F2 cause congenital heart defects in humans publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2014.03.007 contributor: fullname: Al Turki – volume: 307 start-page: 1625 year: 2005 ident: 10.1016/j.devcel.2021.10.018_bib70 article-title: A transmembrane intracellular estrogen receptor mediates rapid cell signaling publication-title: Science doi: 10.1126/science.1106943 contributor: fullname: Revankar – year: 2019 ident: 10.1016/j.devcel.2021.10.018_bib5 article-title: Quantifying the effect of experimental perturbations in single-cell RNA-sequencing data using graph signal processing publication-title: bioRxiv contributor: fullname: Burkhardt – volume: 330 start-page: 444 year: 1987 ident: 10.1016/j.devcel.2021.10.018_bib64 article-title: A human retinoic acid receptor which belongs to the family of nuclear receptors publication-title: Nature doi: 10.1038/330444a0 contributor: fullname: Petkovich – volume: 86 start-page: 3043 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib56 article-title: Lipidomic "deep profiling": an enhanced workflow to reveal new molecular species of signaling lipids publication-title: Anal. Chem. doi: 10.1021/ac4039652 contributor: fullname: Narayanaswamy – volume: 91 start-page: 4451 year: 1994 ident: 10.1016/j.devcel.2021.10.018_bib67 article-title: Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.91.10.4451 contributor: fullname: Qiu – volume: 39 start-page: 428 year: 2012 ident: 10.1016/j.devcel.2021.10.018_bib22 article-title: Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2012.07.007 contributor: fullname: Hermann-Kleiter – volume: 343 start-page: 84 year: 2014 ident: 10.1016/j.devcel.2021.10.018_bib82 article-title: Genome-scale CRISPR-Cas9 knockout screening in human cells publication-title: Science doi: 10.1126/science.1247005 contributor: fullname: Shalem – volume: 9 start-page: 2606 year: 2020 ident: 10.1016/j.devcel.2021.10.018_bib93 article-title: Nuclear hormone receptors and their ligands: metabolites in control of transcription publication-title: Cells doi: 10.3390/cells9122606 contributor: fullname: Tao – volume: 9 start-page: 1765 year: 2017 ident: 10.1016/j.devcel.2021.10.018_bib80 article-title: A COUP-TFII human embryonic stem cell reporter line to identify and select atrial cardiomyocytes publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2017.10.024 contributor: fullname: Schwach – volume: 133 start-page: 3549 year: 2006 ident: 10.1016/j.devcel.2021.10.018_bib59 article-title: Dynamic regulation of Drosophila nuclear receptor activity in vivo publication-title: Development doi: 10.1242/dev.02512 contributor: fullname: Palanker – volume: 285 start-page: 11178 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib61 article-title: Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.092973 contributor: fullname: Penno – volume: 355 start-page: 262 year: 1992 ident: 10.1016/j.devcel.2021.10.018_bib40 article-title: A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension publication-title: Nature doi: 10.1038/355262a0 contributor: fullname: Lifton – volume: 37 start-page: 1482 year: 2019 ident: 10.1016/j.devcel.2021.10.018_bib54 article-title: Visualizing structure and transitions in high-dimensional biological data publication-title: Nat. Biotechnol. doi: 10.1038/s41587-019-0336-3 contributor: fullname: Moon – volume: 3 start-page: 1262 year: 2012 ident: 10.1016/j.devcel.2021.10.018_bib75 article-title: Luminescent proteins for high-speed single-cell and whole-body imaging publication-title: Nat. Commun. doi: 10.1038/ncomms2248 contributor: fullname: Saito – volume: 24 start-page: 696 year: 2010 ident: 10.1016/j.devcel.2021.10.018_bib86 article-title: The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells publication-title: Genes Dev. doi: 10.1101/gad.1859310 contributor: fullname: Srinivasan – volume: 25 start-page: 417 year: 2013 ident: 10.1016/j.devcel.2021.10.018_bib105 article-title: Atrial identity is determined by a COUP-TFII regulatory network publication-title: Dev. Cell doi: 10.1016/j.devcel.2013.04.017 contributor: fullname: Wu |
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| Title | 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development |
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