Moving fast but going slow: coordination challenges for trials of COVID-19 post-exposure prophylaxis

• Published in: Current controlled trials in cardiovascular medicine Vol. 21; no. 1; pp. 815 - 3
• Main Authors: Tan, Darrell H. S., Agrawal, Rupesh, Barnabas, Ruanne V., Giles, Jon T., Dull, Peter
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.09.2020; BioMed Central; BMC
• Subjects: Antiviral Agents - administration & dosage; Antiviral Agents - adverse effects; Betacoronavirus - drug effects; Betacoronavirus - pathogenicity; Canada; Cardiac arrhythmia; Clinical trials; Clinical Trials as Topic; Clinical Trials Data Monitoring Committees - trends; Consent; Cooperative Behavior; Coronavirus Infections - diagnosis; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; Coronaviruses; COVID-19; Disease prevention; Disease transmission; Epidemics; HIV; Host-Pathogen Interactions; Human immunodeficiency virus; Humans; Infections; Medical research; Methods; Mortality; Observational studies; Pandemics; Pandemics - prevention & control; Patient outcomes; Pneumonia, Viral - diagnosis; Pneumonia, Viral - prevention & control; Pneumonia, Viral - virology; Post-Exposure Prophylaxis; Prophylaxis; Research Design - trends; Respiratory diseases; Risk Factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Time Factors; Treatment Outcome; Canada

An unprecedented volume of research has been generated in response to the COVID-19 pandemic. However, there are risks of inefficient duplication and of important work being impeded if efforts are not synchronized. Excessive reliance on observational studies, which can be more rapidly conducted but a...