Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use - Tu, I-Fan; Lin, Tzu-Lung; Yang, Feng-Ling; Lee, I-Ming; Tu, Wei-Lin; Liao, Jiahn-Haur; Ko, Tzu-Ping; Wu, Wen-Jin; Jan, Jia-Tsrong; Ho, Meng-Ru; Chou, Ching-Yi; Wang, Andrew H.-J.; et al. (Journal of biomedical science, 2022)
Keywords: Abscesses; Absorption; Acetates; Acetylation; Animals; Antigenic determinants; Antigens; Bacteria; Bacterial Capsules - genetics; Bacterial pneumonia; Bacteriophages - genetics; Binding sites; Biodegradation; Capsular polysaccharides; Carbohydrates; Chemical compounds; Crystal structure; Crystals; Depolymerization; Enzymes; Experiments; Fragments; Health aspects; Humans; Immune response; Infections; Infectivity; K1 capsular polysaccharide; Kinetics; Klebsiella; Klebsiella Infections; Klebsiella pneumoniae; Klebsiella pnuemoniae; Liver; Lyases; Magnetic resonance spectroscopy; Mass spectrometry; Mass spectroscopy; Meningitis; Mice; Mortality; Mutagenesis; NMR; NMR spectroscopy; Nuclear magnetic resonance; Nuclear magnetic resonance spectroscopy; Oligosaccharides; Phages; Pharmacology; Phospholipase A; Pneumonia; Polysaccharide lyase; Polysaccharides; Proteins; Pyruvic acid; Pyruvylation; Scientific imaging; Site-directed mutagenesis; Structure; Tailspike protein; Taiwan; Vaccines; Taiwan; Pyruvylation; β-Helix; K1 capsular polysaccharide; Tailspike protein; Acetylation; Polysaccharide lyase; Klebsiella pnuemoniae