Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse

• Published in: Journal of translational medicine Vol. 19; no. 1; pp. 428 - 15
• Main Authors: Secchi, Christian, Belli, Martina, Harrison, Tracy N. H., Swift, Joseph, Ko, CheMyong, Duleba, Antoni J., Stupack, Dwayne, Chang, R. Jeffrey, Shimasaki, Shunichi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.10.2021; BioMed Central; BMC
• Subjects: Androgen excess; Androgens; Androgens - pharmacology; Animals; Antibiotics; CYP17; Cytochrome P450 Family 17; Development and progression; Doxycycline; Enzymatic activity; Enzymes; Female; Fertility; Follicles; Folliculogenesis; Gene expression; Genetic aspects; Gonadal disorders; Health aspects; Histology; Humans; Hydrolases; Hydroxylase; LoxP gene; Male; Mice; Morphology; Mouse model; Ovaries; Ovary; Ovulation; Phenotype; Phenotypes; Physiological aspects; Polycystic Ovary Syndrome; Pregnenolone; Progesterone; Proteins; Rodents; Runx1 protein; Stem cells; Steroid 17-alpha-Hydroxylase - genetics; Steroids; Stromal cells; Testosterone; Theca; Theca Cells; Transgender persons; Transgenic animals; Transgenic mice; United States; Ovary; Fertility; Androgen excess; CYP17; Transgender; Mouse model; Theca cells

In the ovarian follicle, the Theca Cells (TCs) have two main functions: preserving morphological integrity and, importantly, secreting steroid androgen hormones. TCs express the essential enzyme 17α-hydroxylase/17,20-desmolase (CYP17), which permits the conversion of pregnenolone and progesterone in...