Using the co-expression network of T cell-activation-related genes to assess the disease activity in Takayasu’s arteritis patients

• Published in: Arthritis research & therapy Vol. 23; no. 1; pp. 303 - 16
• Main Authors: Tian, Yixiao, Li, Jing, Tian, Xinping, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.12.2021; BioMed Central; BMC
• Subjects: Arthritis; Biomarkers; Diagnosis; Disease activity; Gene expression; Genetic aspects; Health aspects; Humans; Lymphocyte Activation - genetics; Mathematical models; Medical diagnosis; mRNA; Patients; Physiological aspects; Remission (Medicine); Risk factors; T cell activation; T cells; T-Lymphocytes - metabolism; Takayasu Arteritis - genetics; Takayasu's arteritis; Tumor necrosis factor-TNF; Vein & artery diseases; China; mRNA; Disease activity; Diagnosis; T cell activation; Takayasu’s arteritis

There have been lacking reliable serum biomarkers in assessing the disease activity of Takayasu's arteritis (TAK). This study aimed to assess the disease activity of TAK by assayed gene expression levels in peripheral mononuclear cells (PBMCs). The expression level of genes that essential in T...