Risk factors influencing survival of acellular porcine corneal stroma in infectious keratitis: a prospective clinical study

• Published in: Journal of translational medicine Vol. 17; no. 1; pp. 434 - 10
• Main Authors: Li, Saiqun, Li, Meng, Gu, Li, Peng, Lulu, Deng, Yuqing, Zhong, Jing, Wang, Bowen, Wang, Qian, Xiao, Yichen, Yuan, Jin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.12.2019; BioMed Central; BMC
• Subjects: Acellular porcine corneal stroma; Acuity; Adolescent; Adult; Aged; Animals; Care and treatment; Clinical trials; Cornea; Corneal Stroma - surgery; Corneal Stroma - transplantation; Corneal Stroma - ultrastructure; Corneal transplantation; Eye surgery; Graft rejection; Graft Survival; Grafts; Humans; Infections; Infectious keratitis; Kaplan-Meier Estimate; Keratitis; Keratitis, Herpetic - pathology; Keratitis, Herpetic - physiopathology; Keratitis, Herpetic - therapy; Medical research; Middle Aged; Neovascularization; Patient outcomes; Patients; Prospective Studies; Recurrence (Disease); Respiratory system agents; Risk Factors; Scanning electron microscopy; Stroma; Surgery; Survival; Swine; Therapeutic lamellar keratoplasty; Treatment Outcome; Vascularization; Viral infections; Visual Acuity; Young Adult; China; Infectious keratitis; Acellular porcine corneal stroma; Therapeutic lamellar keratoplasty

A worldwide lack of donor corneas demands the bioengineered corneas be developed as an alternative. The primary objective of the current study was to evaluate the efficacy of acellular porcine corneal stroma (APCS) transplantation in various types of infectious keratitis and identify risk factors th...