Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption

• Published in: Journal of neuroinflammation Vol. 20; no. 1; pp. 54 - 19
• Main Authors: Qin, Zongshi, Shi, Dong-Dong, Li, Wenqi, Cheng, Dan, Zhang, Ying-Dan, Zhang, Sen, Tsoi, Bun, Zhao, Jia, Wang, Zhen, Zhang, Zhang-Jin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.03.2023; BioMed Central; BMC
• Subjects: Analysis; Animals; Antidepressants; Behavior; Berberine; Care and treatment; Corticosterone; Cytokines; Dendritic spines; Depression; Depression, Mental; Diagnosis; Dosage and administration; Drinking water; Hippocampal plasticity; Hippocampus; Hypotheses; Immune system; Immunofluorescence; Inflammasomes; Inflammation; Male; Mental depression; Mice; Mice, Inbred C57BL; Neurogenesis; Neuroinflammation; Neuroinflammatory Diseases; Neuronal Plasticity; Neuroplasticity; NLR Family, Pyrin Domain-Containing 3 Protein; NLRP3 inflammasome; Oral administration; Pathophysiology; Preferences; Prefrontal cortex; Reverse transcription; Software; Stress response; Sucrose; Synaptic plasticity; Western blotting; Germany; United States > US; Berberine; Depression; Neuroinflammation; NLRP3 inflammasome; Synaptic plasticity

Neuroinflammation has been suggested that affects the processing of depression. There is renewed interest in berberine owing to its anti-inflammatory effects. Herein, we investigated whether berberine attenuate depressive-like behaviors via inhibiting NLRP3 inflammasome activation in mice model of d...