Solving neurodegeneration: common mechanisms and strategies for new treatments

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Founda...

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Published inMolecular neurodegeneration Vol. 17; no. 1; pp. 23 - 29
Main Authors Wareham, Lauren K., Liddelow, Shane A., Temple, Sally, Benowitz, Larry I., Di Polo, Adriana, Wellington, Cheryl, Goldberg, Jeffrey L., He, Zhigang, Duan, Xin, Bu, Guojun, Davis, Albert A., Shekhar, Karthik, Torre, Anna La, Chan, David C., Canto-Soler, M. Valeria, Flanagan, John G., Subramanian, Preeti, Rossi, Sharyn, Brunner, Thomas, Bovenkamp, Diane E., Calkins, David J.
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 21.03.2022
BioMed Central
BMC
Subjects
Age
Alzheimer's disease
Amyotrophic lateral sclerosis
Bioenergetics
Biomechanics
Blindness
Brain research
Care and treatment
Central nervous system
Cognitive ability
Dementia
Development and progression
Etiology
Extracellular matrix
Fatalities
Genetics
Glaucoma
Glaucoma - pathology
Health aspects
Humans
Huntington’s Disease
Inflammation
Metabolism
Nervous system
Nervous system diseases
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - therapy
Neurons
Neuroprotection
Optic nerve
Optic Nerve - pathology
Parkinson's disease
Pathogenesis
Pathophysiology
Protection and preservation
Proteins
Regeneration
Review
Therapeutic targets
Glaucoma
Model Systems
Biomarker
Huntington’s Disease
Alzheimer’s Disease
Neuro-regeneration
Neuro-replacement
Organoids
Neurodegeneration
Imaging
Cell-replacement
Genetics
Parkinson’s Disease
Detection
Glia
Metabolic stress
Neurovascular coupling
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Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled “Solving Neurodegeneration”. This “think-tank” style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world’s leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.
AbstractList Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled “Solving Neurodegeneration”. This “think-tank” style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world’s leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled "Solving Neurodegeneration". This "think-tank" style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world's leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled "Solving Neurodegeneration". This "think-tank" style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world's leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled “Solving Neurodegeneration”. This “think-tank” style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world’s leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled "Solving Neurodegeneration". This "think-tank" style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world's leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss. Keywords: Neurodegeneration, Alzheimer's Disease, Glaucoma, Parkinson's Disease, Huntington's Disease, Genetics, Metabolic stress, Neuro-regeneration, Neuro-replacement, Neurovascular coupling, Biomarker, Cell-replacement, Detection, Glia, Imaging, Model Systems, Organoids
ArticleNumber 23
Audience Academic
Author Wareham, Lauren K.
Subramanian, Preeti
Torre, Anna La
He, Zhigang
Brunner, Thomas
Liddelow, Shane A.
Goldberg, Jeffrey L.
Canto-Soler, M. Valeria
Calkins, David J.
Duan, Xin
Flanagan, John G.
Temple, Sally
Wellington, Cheryl
Bovenkamp, Diane E.
Bu, Guojun
Rossi, Sharyn
Di Polo, Adriana
Shekhar, Karthik
Chan, David C.
Benowitz, Larry I.
Davis, Albert A.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35313950$$D View this record in MEDLINE/PubMed
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Keywords Glaucoma
Model Systems
Biomarker
Huntington’s Disease
Alzheimer’s Disease
Neuro-regeneration
Neuro-replacement
Organoids
Neurodegeneration
Imaging
Cell-replacement
Genetics
Parkinson’s Disease
Detection
Glia
Metabolic stress
Neurovascular coupling
Language English
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Snippet Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of...
Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration,...
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StartPage 23
SubjectTerms Age
Alzheimer's disease
Amyotrophic lateral sclerosis
Bioenergetics
Biomechanics
Blindness
Brain research
Care and treatment
Central nervous system
Cognitive ability
Dementia
Development and progression
Etiology
Extracellular matrix
Fatalities
Genetics
Glaucoma
Glaucoma - pathology
Health aspects
Humans
Huntington’s Disease
Inflammation
Metabolism
Nervous system
Nervous system diseases
Neurodegeneration
Neurodegenerative diseases
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - therapy
Neurons
Neuroprotection
Optic nerve
Optic Nerve - pathology
Parkinson's disease
Pathogenesis
Pathophysiology
Protection and preservation
Proteins
Regeneration
Review
Therapeutic targets
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Title Solving neurodegeneration: common mechanisms and strategies for new treatments
URI https://www.ncbi.nlm.nih.gov/pubmed/35313950
https://www.proquest.com/docview/2652318677
https://www.proquest.com/docview/2641859217
https://pubmed.ncbi.nlm.nih.gov/PMC8935795
https://doaj.org/article/c304792ddb214075a9d068c15e1e5d12
Volume 17
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