Identification of tumor tissue-derived DNA methylation biomarkers for the detection and therapy response evaluation of metastatic castration resistant prostate cancer in liquid biopsies

• Published in: Molecular cancer Vol. 21; no. 1; pp. 7 - 8
• Main Authors: Dillinger, Thomas, Sheibani-Tezerji, Raheleh, Pulverer, Walter, Stelzer, Ines, Hassler, Melanie R., Scheibelreiter, Janine, Pérez Malla, Carlos Uziel, Kuroll, Madeleine, Domazet, Sandra, Redl, Elisa, Ely, Sarah, Brezina, Stefanie, Tiefenbacher, Andreas, Rebhan, Katharina, Hübner, Nicolai, Grubmüller, Bernhard, Mitterhauser, Markus, Hacker, Marcus, Weinhaeusel, Andreas, Simon, Judit, Zeitlinger, Markus, Gsur, Andrea, Kramer, Gero, Shariat, Shahrokh F., Kenner, Lukas, Egger, Gerda
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.01.2022; BioMed Central; BMC
• Subjects: Analysis; Androgens; Bayesian analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Breast cancer; Cancer; Cancer therapies; Candidates; Castration; Computational Biology - methods; Computed tomography; Deoxyribonucleic acid; Development and progression; Discriminant analysis; Disease Management; Disease Susceptibility; DNA; DNA Methylation; Epigenesis, Genetic; Epigenetics; Epigenomics - methods; Gene Expression Profiling; Genes; Genetic aspects; Humans; Letter to the Editor; Liquid Biopsy - methods; Male; Mathematical models; Metastases; Metastasis; Methylation; Nearest-neighbor; Patients; Plasma; Prediction models; Prognosis; Prostate cancer; Prostatic Neoplasms, Castration-Resistant - blood; Prostatic Neoplasms, Castration-Resistant - diagnosis; Prostatic Neoplasms, Castration-Resistant - genetics; Prostatic Neoplasms, Castration-Resistant - therapy; Risk groups; Treatment Outcome; Tumors

Aside from genetic alterations, epigenetic tumor-specific changes including DNA methylation are measurable in ctDNA and CTCs and their potential as diagnostic, prognostic and predictive epigenetic biomarkers has been demonstrated in a large number of studies although only few have made it into clini...