Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin

• Published in: mBio Vol. 8; no. 1
• Main Authors: Nao, Naganori, Yamagishi, Junya, Miyamoto, Hiroko, Igarashi, Manabu, Manzoor, Rashid, Ohnuma, Aiko, Tsuda, Yoshimi, Furuyama, Wakako, Shigeno, Asako, Kajihara, Masahiro, Kishida, Noriko, Yoshida, Reiko, Takada, Ayato
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.01.2017
• Subjects: Adenine - chemistry; Animals; Chickens - virology; Genetic Predisposition to Disease; Guanine - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - classification; Hemagglutinin Glycoproteins, Influenza Virus - genetics; High-Throughput Nucleotide Sequencing; Influenza A Virus, H5N1 Subtype - chemistry; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza in Birds; RNA, Viral - chemistry; RNA, Viral - genetics; Virulence

Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observed to occur naturally only in these HA subtypes, li...