MicroRNA-320a: an important regulator in the fibrotic process in interstitial lung disease of systemic sclerosis

• Published in: Arthritis research & therapy Vol. 23; no. 1; pp. 21 - 11
• Main Authors: Li, Yiqun, Huang, Jing, Hu, Chaojun, Zhou, Jiaxin, Xu, Dong, Hou, Yong, Wu, Chanyuan, Zhao, Jiuliang, Li, Mengtao, Zeng, Xiaofeng, Liu, Changzheng, Wang, Qian, Zhao, Yan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.01.2021; BioMed Central; BMC
• Subjects: Antibodies; Anticoagulants; Arthritis; Binding sites; Care and treatment; Collagen; Collagen Type I; Fibroblasts; Fibrosis; Genes; Health aspects; Humans; IGF-1; Interstitial lung disease; Lung diseases; Lung Diseases, Interstitial - genetics; Medical research; MicroRNA; MicroRNAs; MicroRNAs - genetics; miR-320a; Mutation; Pathogenesis; Properties; Quality control; Rheumatism; Scleroderma; Scleroderma (Disease); Scleroderma, Systemic - genetics; Systemic scleroderma; Systemic sclerosis; TGF-β; China; United States > US; Japan; TGF-β; IGF-1; miR-320a; Interstitial lung disease; Systemic sclerosis

Systemic sclerosis (SSc) is an acquired autoimmune disorder characterized by excessive accumulation of collagen and progressive tissue fibrosis. Although interstitial lung disease (ILD) complicates the majority of SSc patients and is the leading cause of death, its pathogenesis remains largely uncle...