Insights into N6-methyladenosine and programmed cell death in cancer

N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending...

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Published inMolecular cancer Vol. 21; no. 1; pp. 32 - 16
Main Authors Liu, Li, Li, Hui, Hu, Dingyu, Wang, Yanyan, Shao, Wenjun, Zhong, Jing, Yang, Shudong, Liu, Jing, Zhang, Ji
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 28.01.2022
BioMed Central
BMC
Subjects
Apoptosis
Autophagy
Biochemistry
Biosynthesis
Cancer
Cell cycle
Cell death
Development and progression
Drug resistance
Ferroptosis
Gene expression
Homeostasis
Metabolism
Methylation
Methyltransferases
N6-methyladenosine
Necroptosis
Proteins
Pyroptosis
Review
RNA
RNA modification
Tumorigenesis
Type 2 diabetes
Writers
Pyroptosis
Necroptosis
Ferroptosis
N6-methyladenosine
Autophagy
Apoptosis
Cancer
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Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application.
AbstractList N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application.
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application.
N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application.N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application.
N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and different types of PCD pathways, which are then closely associated with the initiation, progression and resistance of cancer. Herein, clarifying the relationship between m6A and PCD is of great significance to provide novel strategies for cancer treatment, and has a great potential prospect of clinical application. Keywords: N6-methyladenosine, Cancer, Apoptosis, Autophagy, Pyroptosis, Ferroptosis, Necroptosis
ArticleNumber 32
Audience Academic
Author Zhong, Jing
Liu, Li
Wang, Yanyan
Liu, Jing
Hu, Dingyu
Zhang, Ji
Li, Hui
Yang, Shudong
Shao, Wenjun
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– sequence: 2
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  givenname: Dingyu
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  fullname: Hu, Dingyu
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  givenname: Yanyan
  surname: Wang
  fullname: Wang, Yanyan
– sequence: 5
  givenname: Wenjun
  surname: Shao
  fullname: Shao, Wenjun
– sequence: 6
  givenname: Jing
  surname: Zhong
  fullname: Zhong, Jing
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  surname: Yang
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  orcidid: 0000-0002-6610-9805
  surname: Zhang
  fullname: Zhang, Ji
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35090469$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Pyroptosis
Necroptosis
Ferroptosis
N6-methyladenosine
Autophagy
Apoptosis
Cancer
Language English
License 2022. The Author(s).
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Snippet N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot...
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a...
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pubmedcentral
proquest
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pubmed
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Open Access Repository
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Enrichment Source
StartPage 32
SubjectTerms Apoptosis
Autophagy
Biochemistry
Biosynthesis
Cancer
Cell cycle
Cell death
Development and progression
Drug resistance
Ferroptosis
Gene expression
Homeostasis
Metabolism
Methylation
Methyltransferases
N6-methyladenosine
Necroptosis
Proteins
Pyroptosis
Review
RNA
RNA modification
Tumorigenesis
Type 2 diabetes
Writers
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Title Insights into N6-methyladenosine and programmed cell death in cancer
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Volume 21
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