Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma

• Published in: Molecular cancer Vol. 20; no. 1; pp. 10 - 17
• Main Authors: Guo, Jianfeng, Yu, Zhuo, Sun, Dandan, Zou, Yifang, Liu, Yun, Huang, Leaf
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.01.2021; BioMed Central; BMC
• Subjects: 5-Fluorouracil; Analysis; Animal models; Animals; Antigens; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Apoptosis; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - metabolism; Biochemistry; Cancer; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - immunology; Cell death; Cell Line, Tumor; Chemotherapy; Cholesterol; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - immunology; Combination therapy; Disease Models, Animal; Drug Compounding; Drug delivery; Drug delivery systems; Drug Synergism; Drug therapy; Drugs; Ethanol; Female; Fluorodeoxyuridylate - metabolism; Fluorouracil - pharmacology; Fluorouracil - therapeutic use; Folinic acid; Hepatocellular carcinoma; Hepatoma; Immune response; Immunogenetics; Immunogenic cell death; Immunogenic Cell Death - drug effects; Immunogenicity; Immunotherapy; Leucovorin; Leucovorin - pharmacology; Leucovorin - therapeutic use; Lipids; Liver; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Lymphocytes; Metabolites; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Microemulsions; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Neoplasm Metastasis; Organoplatinum Compounds - pharmacology; Organoplatinum Compounds - therapeutic use; Oxaliplatin; PD-L1 protein; Polyethylene glycol; Reactive oxygen species; Reactive Oxygen Species - metabolism; Tissue Distribution; Tumors; Vehicles; Nanoparticles; Reactive oxygen species; Drug delivery; Combination therapy; Immunogenic cell death

FOLFOX is a combinational regimen of folinic acid (FnA, FOL), fluorouracil (5-Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of colorectal cancer (CRC) and hepatocellular carcinoma (HCC). Recent developments of nano delivery systems have provided profound pr...