Saccharomyces boulardii improves the behaviour and emotions of spastic cerebral palsy rats through the gut-brain axis pathway

• Published in: BMC neuroscience Vol. 22; no. 1; pp. 76 - 16
• Main Authors: Tao, Deshuang, Zhong, Tangwu, Pang, Wei, li, Xiaojie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.12.2021; BioMed Central; BMC
• Subjects: Adrenocorticotropic hormone; Animal model; Animal models; Animals; Brain-Gut Axis - physiology; Care and treatment; Cerebral palsy; Cerebral Palsy - microbiology; Corticosterone; Cytokines; Digestive system; Emotions; Emotions - physiology; Gut microbiome; Gut-brain axis; Health aspects; Hemiplegic spastic cerebral palsy; HPA axis; Hyperbilirubinemia; Hypothalamic-pituitary-adrenal axis; Hypothalamo-Hypophyseal System - microbiology; Hypothalamus; Inflammation; Interleukin 6; Intestinal microflora; Medical research; Medicine, Experimental; Mental depression; Mental illness; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Paralysis; Pituitary; Pituitary-Adrenal System - microbiology; Probiotics; Probiotics - administration & dosage; Rats; Rats, Sprague-Dawley; rRNA 16S; Saccharomyces boulardii; Saccharomyces boulardii - pathogenicity; Spasticity; Substantia alba; Tumor necrosis factor-α; China; Animal model; Saccharomyces boulardii; Hemiplegic spastic cerebral palsy; Gut-brain axis; Depression-like behaviour; HPA axis; Immune regulation; Inflammation; Gut microbiome; probiotics

Cerebral palsy (CP) is a kind of disability that influences motion, and children with CP also exhibit depression-like behaviour. Inflammation has been recognized as a contributor to CP and depression, and some studies suggest that the gut-brain axis may be a contributing factor. Our team observed th...