PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells

• Published in: BMC musculoskeletal disorders Vol. 22; no. 1; p. 959
• Main Authors: Quinelato, Valquiria, Bonato, Letícia Ladeira, Vieira, Alexandre Rezende, Granjeiro, José Mauro, Menezes, Karla, Borojevic, Radovan, Casado, Priscila Ladeira, Calasans-Maia, Jose Albuquerque, Tesch, Ricardo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.11.2021; BioMed Central; BMC
• Subjects: Case-Control Studies; Chronic Pain; Complications and side effects; Diagnosis; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genotyping; Health aspects; Humans; Hypotheses; Inflammation; Mastication; Muscles; Musculoskeletal diseases; Musculoskeletal system; Myalgia; Pain; PAX7 Transcription Factor - genetics; Polymorphism genetic; Polymorphism, Single Nucleotide; Risk factors; Saliva; Single-nucleotide polymorphism; Statistical analysis; Stem Cells; Temporomandibular joint; Temporomandibular joint disorders; Temporomandibular Joint Disorders - diagnosis; Temporomandibular Joint Disorders - epidemiology; Temporomandibular Joint Disorders - genetics; Temporomandibular joint dysfunction syndrome; Brazil; United States > US; Myalgia; Polymorphism genetic; Temporomandibular joint dysfunction syndrome; Chronic pain

Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. To evaluate the association between polymorphi...