PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells

Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. To evaluate the association between polymorphi...

Full description

Saved in:
Bibliographic Details
Published inBMC musculoskeletal disorders Vol. 22; no. 1; p. 959
Main Authors Quinelato, Valquiria, Bonato, Letícia Ladeira, Vieira, Alexandre Rezende, Granjeiro, José Mauro, Menezes, Karla, Borojevic, Radovan, Casado, Priscila Ladeira, Calasans-Maia, Jose Albuquerque, Tesch, Ricardo
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 17.11.2021
BioMed Central
BMC
Subjects
Case-Control Studies
Chronic Pain
Complications and side effects
Diagnosis
Gene polymorphism
Genetic aspects
Genetic polymorphisms
Genotyping
Health aspects
Humans
Hypotheses
Inflammation
Mastication
Muscles
Musculoskeletal diseases
Musculoskeletal system
Myalgia
Pain
PAX7 Transcription Factor - genetics
Polymorphism genetic
Polymorphism, Single Nucleotide
Risk factors
Saliva
Single-nucleotide polymorphism
Statistical analysis
Stem Cells
Temporomandibular joint
Temporomandibular joint disorders
Temporomandibular Joint Disorders - diagnosis
Temporomandibular Joint Disorders - epidemiology
Temporomandibular Joint Disorders - genetics
Temporomandibular joint dysfunction syndrome
Brazil
United States > US
Myalgia
Polymorphism genetic
Temporomandibular joint dysfunction syndrome
Chronic pain
Online AccessGet full text

Cover

Abstract Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher's exact tests. Values of p < 0.05 were considered to be statistically significant. Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.
AbstractList Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. Objective To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). Materials and methods This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher’s exact tests. Values of p < 0.05 were considered to be statistically significant. Results Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Conclusions Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.
Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher's exact tests. Values of p < 0.05 were considered to be statistically significant. Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.
Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. Objective To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). Materials and methods This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher's exact tests. Values of p < 0.05 were considered to be statistically significant. Results Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Conclusions Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325. Keywords: Chronic pain, Temporomandibular joint dysfunction syndrome, Myalgia, Polymorphism genetic
BACKGROUNDTemporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. OBJECTIVETo evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). MATERIALS AND METHODSThis is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher's exact tests. Values of p < 0.05 were considered to be statistically significant. RESULTSIndividuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. CONCLUSIONSAlterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.
Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher's exact tests. Values of p < 0.05 were considered to be statistically significant. Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.
Abstract Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. Objective To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). Materials and methods This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher’s exact tests. Values of p < 0.05 were considered to be statistically significant. Results Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Conclusions Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.
ArticleNumber 959
Audience Academic
Author Quinelato, Valquiria
Borojevic, Radovan
Casado, Priscila Ladeira
Calasans-Maia, Jose Albuquerque
Vieira, Alexandre Rezende
Tesch, Ricardo
Menezes, Karla
Bonato, Letícia Ladeira
Granjeiro, José Mauro
Author_xml – sequence: 1
  givenname: Valquiria
  surname: Quinelato
  fullname: Quinelato, Valquiria
  email: valquiriaquinelato@yahoo.com.br
  organization: School of Dentistry, Universidade Federal Fluminense, Mario Santos Braga St, 28 - Center, Niterói, RJ, 24020-140, Brazil. valquiriaquinelato@yahoo.com.br
– sequence: 2
  givenname: Letícia Ladeira
  surname: Bonato
  fullname: Bonato, Letícia Ladeira
  organization: School of Dentistry, Universidade Federal Fluminense, Mario Santos Braga St, 28 - Center, Niterói, RJ, 24020-140, Brazil
– sequence: 3
  givenname: Alexandre Rezende
  surname: Vieira
  fullname: Vieira, Alexandre Rezende
  organization: University of Pittsburgh School of Dental Medicine, Pittsburgh, USA
– sequence: 4
  givenname: José Mauro
  surname: Granjeiro
  fullname: Granjeiro, José Mauro
  organization: National Institute of Metrology, Quality and Technology, Rio de Janeiro, Brazil
– sequence: 5
  givenname: Karla
  surname: Menezes
  fullname: Menezes, Karla
  organization: School of Medicine of Petropolis, Petropolis, Brazil
– sequence: 6
  givenname: Radovan
  surname: Borojevic
  fullname: Borojevic, Radovan
  organization: School of Medicine of Petropolis, Petropolis, Brazil
– sequence: 7
  givenname: Priscila Ladeira
  surname: Casado
  fullname: Casado, Priscila Ladeira
  organization: School of Dentistry, Universidade Federal Fluminense, Mario Santos Braga St, 28 - Center, Niterói, RJ, 24020-140, Brazil
– sequence: 8
  givenname: Jose Albuquerque
  surname: Calasans-Maia
  fullname: Calasans-Maia, Jose Albuquerque
  organization: School of Dentistry, Universidade Federal Fluminense, Mario Santos Braga St, 28 - Center, Niterói, RJ, 24020-140, Brazil
– sequence: 9
  givenname: Ricardo
  surname: Tesch
  fullname: Tesch, Ricardo
  organization: School of Medicine of Petropolis, Petropolis, Brazil
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34789211$$D View this record in MEDLINE/PubMed
BookMark eNptUstq3DAUFSWlSab9gS6KoZtunEqyrMemMIQ-AoF20UJ3QpavJhpsy5XshPn7yjN5TSlCSFydc6Rzdc7RyRAGQOgtwReESP4xESoVKTHNk0nGy7sX6IwwQUrKBDt5tj9F5yltMSZCVuoVOq2YkIoScoa2P9a_RbGBAYoxdLs-xPHGp77wQ9HPyc6dicUE_Rhi6M3Q-mZfaX0KsYWYCpMyb4Jh8qbrdkWEzkzQFlPY0zsoUmYXFrouvUYvnekSvLlfV-jXl88_L7-V19-_Xl2ur0tb82oqpXKEMMUYExQDVhIbB4yzGkMjbe2gIZLwCosGM0zrymIpQFa1sQKUJKJaoauDbhvMVo_R9ybudDBe7wshbrSJk8-P05SDaJStGmdqBkpl6YbxhjlHlAHVZq1PB61xbnpobTYaTXckenwy-Bu9CbdacoxF9rNCH-4FYvgzQ5p079PSDjNAmJOmtVIZWHOWoe__gW7DHIfcqgWV_0txUT-hNiYb8IML-V67iOo1l5xxKuWidfEfVB4t9N7mGDmf60cEeiDYGFKK4B49EqyXtOlD2nROm96nTd9l0rvn3XmkPMSr-gt9ZdIX
CitedBy_id crossref_primary_10_3390_jfb14020103
Cites_doi 10.1177/0022034515581643
10.1002/sctm.19-0447
10.1136/bjsm.2008.051193
10.1083/jcb.200312007
10.14814/phy2.14200
10.1172/JCI40373
10.1590/s1678-77572012000400013
10.1007/s12035-014-8790-x
10.1016/j.ijsu.2014.07.013
10.1016/j.jbiomech.2014.08.010
10.1016/j.jpain.2013.07.018
10.1186/s10194-017-0737-y
10.1152/jappl.2001.91.2.534
10.1007/s00439-008-0592-7
10.1097/gim.0b013e3181833793
10.1111/j.1582-4934.2011.01348.x
10.1177/0022034519837249
10.1111/j.1601-0825.2006.01353.x
10.1016/j.jpor.2017.09.003
10.1111/j.1600-0838.2010.01178.x
10.1016/s0092-8674(00)00066-0
10.1097/j.pain.0000000000001864
10.1083/jcb.200408066
10.1016/j.ijom.2019.06.027
10.1007/s004180050348
10.1111/j.1365-2842.2010.02074.x
10.1007/s00018-019-03093-6
10.1097/MD.0000000000006724
10.1038/ejhg.2008.250
10.1016/j.jpain.2013.09.004
10.1016/j.neuroscience.2010.07.041
10.1146/annurev.cellbio.23.090506.123438
10.1113/jphysiol.2007.128827
ContentType Journal Article
Copyright 2021. The Author(s).
COPYRIGHT 2021 BioMed Central Ltd.
2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2021
Copyright_xml – notice: 2021. The Author(s).
– notice: COPYRIGHT 2021 BioMed Central Ltd.
– notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2021
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QP
7RV
7TK
7TS
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
KB0
M0S
M1P
NAPCQ
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1186/s12891-021-04846-w
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
ProQuest Nursing and Allied Health Journals
Neurosciences Abstracts
Physical Education Index
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Health & Medical Collection (Alumni Edition)
Medical Database
Nursing & Allied Health Premium
Publicly Available Content (ProQuest)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Central China
Physical Education Index
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database


MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1471-2474
EndPage 959
ExternalDocumentID oai_doaj_org_article_26e7b9c3bfa54e99b18b46b4ff19ae9d
A686462884
10_1186_s12891_021_04846_w
34789211
Genre Journal Article
GeographicLocations Brazil
United States--US
GeographicLocations_xml – name: Brazil
– name: United States--US
GroupedDBID ---
-A0
0R~
23N
2WC
3V.
53G
5VS
6J9
6PF
7RV
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AAWTL
ABDBF
ABUWG
ACGFO
ACGFS
ACIHN
ACPRK
ACRMQ
ADBBV
ADINQ
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C24
C6C
CCPQU
CGR
CS3
CUY
CVF
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBLON
EBS
ECM
EIF
EMB
EMK
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HMCUK
IAO
IHR
INH
INR
ITC
KQ8
M1P
M48
M~E
NAPCQ
NPM
O5R
O5S
OK1
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
RNS
ROL
RPM
RSV
SMD
SOJ
SV3
TR2
TUS
U2A
UKHRP
W2D
WOQ
WOW
XSB
AAYXX
CITATION
7QP
7TK
7TS
7XB
8FK
AZQEC
DWQXO
K9.
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c563t-89f1149444720e0980afe46450eb8c5feb1816307b040253c087e835ac7e98173
IEDL.DBID RPM
ISSN 1471-2474
IngestDate Tue Oct 22 15:06:48 EDT 2024
Tue Sep 17 21:27:20 EDT 2024
Fri Oct 25 08:50:27 EDT 2024
Thu Oct 10 19:47:19 EDT 2024
Tue Nov 19 21:05:52 EST 2024
Tue Nov 12 23:26:16 EST 2024
Fri Nov 22 00:18:56 EST 2024
Sat Sep 28 08:19:08 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Myalgia
Polymorphism genetic
Temporomandibular joint dysfunction syndrome
Chronic pain
Language English
License 2021. The Author(s).
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c563t-89f1149444720e0980afe46450eb8c5feb1816307b040253c087e835ac7e98173
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600756/
PMID 34789211
PQID 2598929675
PQPubID 44767
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_26e7b9c3bfa54e99b18b46b4ff19ae9d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8600756
proquest_miscellaneous_2599075564
proquest_journals_2598929675
gale_infotracmisc_A686462884
gale_infotracacademiconefile_A686462884
crossref_primary_10_1186_s12891_021_04846_w
pubmed_primary_34789211
PublicationCentury 2000
PublicationDate 2021-11-17
PublicationDateYYYYMMDD 2021-11-17
PublicationDate_xml – month: 11
  year: 2021
  text: 2021-11-17
  day: 17
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle BMC musculoskeletal disorders
PublicationTitleAlternate BMC Musculoskelet Disord
PublicationYear 2021
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References M Moayedi (4846_CR6) 2020; 161
P Seale (4846_CR18) 2000; 102
AR Vieira (4846_CR29) 2008; 10
JL Cook (4846_CR9) 2009; 43
TJ Hawke (4846_CR14) 1985; 91
HC Olguín (4846_CR21) 2012; 16
SF Dworkin (4846_CR25) 1992; 6
SB Smith (4846_CR2) 2013; 14
J Fang (4846_CR35) 2020; 9
CG da Fontoura (4846_CR30) 2015; 94
AL Mackey (4846_CR16) 2011; 21
E Von Elm (4846_CR23) 2014; 12
SL Jounger (4846_CR7) 2017; 18
M Buckingham (4846_CR19) 2007; 23
JW Sull (4846_CR31) 2009; 17
NC Jones (4846_CR33) 2005; 169
FS Tedesco (4846_CR20) 2010; 120
M Schmidt (4846_CR13) 2019; 76
F Kadi (4846_CR15) 1999; 111
PS Zammit (4846_CR34) 2004; 166
EC Kuchler (4846_CR26) 2012; 20
Q Guo (4846_CR32) 2017; 96
R Ohrbach (4846_CR3) 2013; 14
MB Elliott (4846_CR8) 2010; 170
MD Da Silva (4846_CR11) 2015; 51
LK McLoon (4846_CR17) 2007; 13
AH Mude (4846_CR4) 2018; 62
ER Hunt (4846_CR12) 2019; 7
RS Tesch (4846_CR24) 2019; 49
O Plesh (4846_CR28) 2011; 25
RM Crameri (4846_CR22) 2007; 583
NM Fiorentino (4846_CR10) 2014; 47
N Shah (4846_CR5) 2019; 98
BE Cairns (4846_CR1) 2010; 37
J Little (4846_CR27) 2009; 125
References_xml – volume: 94
  start-page: 913
  year: 2015
  ident: 4846_CR30
  publication-title: J Dent Res
  doi: 10.1177/0022034515581643
  contributor:
    fullname: CG da Fontoura
– volume: 9
  start-page: 1
  year: 2020
  ident: 4846_CR35
  publication-title: Stem Cells Transl Med
  doi: 10.1002/sctm.19-0447
  contributor:
    fullname: J Fang
– volume: 43
  start-page: 409
  year: 2009
  ident: 4846_CR9
  publication-title: Br J Sports Med
  doi: 10.1136/bjsm.2008.051193
  contributor:
    fullname: JL Cook
– volume: 166
  start-page: 347
  year: 2004
  ident: 4846_CR34
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200312007
  contributor:
    fullname: PS Zammit
– volume: 7
  start-page: e14200
  year: 2019
  ident: 4846_CR12
  publication-title: Physiol Rep
  doi: 10.14814/phy2.14200
  contributor:
    fullname: ER Hunt
– volume: 120
  start-page: 11
  year: 2010
  ident: 4846_CR20
  publication-title: J Clin Invest
  doi: 10.1172/JCI40373
  contributor:
    fullname: FS Tedesco
– volume: 20
  start-page: 467
  year: 2012
  ident: 4846_CR26
  publication-title: J Appl Oral Sci
  doi: 10.1590/s1678-77572012000400013
  contributor:
    fullname: EC Kuchler
– volume: 51
  start-page: 19
  year: 2015
  ident: 4846_CR11
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-014-8790-x
  contributor:
    fullname: MD Da Silva
– volume: 25
  start-page: 190
  year: 2011
  ident: 4846_CR28
  publication-title: J Orofacial Pain
  contributor:
    fullname: O Plesh
– volume: 12
  start-page: 1495
  year: 2014
  ident: 4846_CR23
  publication-title: Int J Surg
  doi: 10.1016/j.ijsu.2014.07.013
  contributor:
    fullname: E Von Elm
– volume: 47
  start-page: 3325
  year: 2014
  ident: 4846_CR10
  publication-title: J Biomech
  doi: 10.1016/j.jbiomech.2014.08.010
  contributor:
    fullname: NM Fiorentino
– volume: 14
  start-page: T33
  year: 2013
  ident: 4846_CR3
  publication-title: J Pain
  doi: 10.1016/j.jpain.2013.07.018
  contributor:
    fullname: R Ohrbach
– volume: 18
  start-page: 30
  year: 2017
  ident: 4846_CR7
  publication-title: J Headache Pain
  doi: 10.1186/s10194-017-0737-y
  contributor:
    fullname: SL Jounger
– volume: 91
  start-page: 534
  year: 1985
  ident: 4846_CR14
  publication-title: J Appl Physiol
  doi: 10.1152/jappl.2001.91.2.534
  contributor:
    fullname: TJ Hawke
– volume: 125
  start-page: 131
  year: 2009
  ident: 4846_CR27
  publication-title: Hum Genet
  doi: 10.1007/s00439-008-0592-7
  contributor:
    fullname: J Little
– volume: 10
  start-page: 668
  year: 2008
  ident: 4846_CR29
  publication-title: Genet Med
  doi: 10.1097/gim.0b013e3181833793
  contributor:
    fullname: AR Vieira
– volume: 16
  start-page: 1013
  year: 2012
  ident: 4846_CR21
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2011.01348.x
  contributor:
    fullname: HC Olguín
– volume: 98
  start-page: 666
  year: 2019
  ident: 4846_CR5
  publication-title: J Dent Res
  doi: 10.1177/0022034519837249
  contributor:
    fullname: N Shah
– volume: 13
  start-page: 134
  year: 2007
  ident: 4846_CR17
  publication-title: Oral Dis
  doi: 10.1111/j.1601-0825.2006.01353.x
  contributor:
    fullname: LK McLoon
– volume: 62
  start-page: 234
  year: 2018
  ident: 4846_CR4
  publication-title: J Prosthodont Res
  doi: 10.1016/j.jpor.2017.09.003
  contributor:
    fullname: AH Mude
– volume: 21
  start-page: 773
  year: 2011
  ident: 4846_CR16
  publication-title: Scand J Med Sci Sports
  doi: 10.1111/j.1600-0838.2010.01178.x
  contributor:
    fullname: AL Mackey
– volume: 102
  start-page: 777
  year: 2000
  ident: 4846_CR18
  publication-title: Cell
  doi: 10.1016/s0092-8674(00)00066-0
  contributor:
    fullname: P Seale
– volume: 161
  start-page: 1787
  year: 2020
  ident: 4846_CR6
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000001864
  contributor:
    fullname: M Moayedi
– volume: 169
  start-page: 105
  year: 2005
  ident: 4846_CR33
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200408066
  contributor:
    fullname: NC Jones
– volume: 49
  start-page: 237
  year: 2019
  ident: 4846_CR24
  publication-title: Int J Oral Maxillofac Surg
  doi: 10.1016/j.ijom.2019.06.027
  contributor:
    fullname: RS Tesch
– volume: 111
  start-page: 189
  year: 1999
  ident: 4846_CR15
  publication-title: Histochem Cell Biol
  doi: 10.1007/s004180050348
  contributor:
    fullname: F Kadi
– volume: 6
  start-page: 301
  year: 1992
  ident: 4846_CR25
  publication-title: J Craniomand Disord
  contributor:
    fullname: SF Dworkin
– volume: 37
  start-page: 391
  year: 2010
  ident: 4846_CR1
  publication-title: J Oral Rehabil
  doi: 10.1111/j.1365-2842.2010.02074.x
  contributor:
    fullname: BE Cairns
– volume: 76
  start-page: 2559
  year: 2019
  ident: 4846_CR13
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-019-03093-6
  contributor:
    fullname: M Schmidt
– volume: 96
  start-page: e6724
  year: 2017
  ident: 4846_CR32
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000006724
  contributor:
    fullname: Q Guo
– volume: 17
  start-page: 831
  year: 2009
  ident: 4846_CR31
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2008.250
  contributor:
    fullname: JW Sull
– volume: 14
  start-page: T91
  year: 2013
  ident: 4846_CR2
  publication-title: J Pain
  doi: 10.1016/j.jpain.2013.09.004
  contributor:
    fullname: SB Smith
– volume: 170
  start-page: 929
  year: 2010
  ident: 4846_CR8
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.07.041
  contributor:
    fullname: MB Elliott
– volume: 23
  start-page: 645
  year: 2007
  ident: 4846_CR19
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev.cellbio.23.090506.123438
  contributor:
    fullname: M Buckingham
– volume: 583
  start-page: 365
  year: 2007
  ident: 4846_CR22
  publication-title: J Physiol
  doi: 10.1113/jphysiol.2007.128827
  contributor:
    fullname: RM Crameri
SSID ssj0017839
Score 2.3595922
Snippet Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint...
Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular...
BACKGROUNDTemporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular...
Abstract Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the...
SourceID doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 959
SubjectTerms Case-Control Studies
Chronic Pain
Complications and side effects
Diagnosis
Gene polymorphism
Genetic aspects
Genetic polymorphisms
Genotyping
Health aspects
Humans
Hypotheses
Inflammation
Mastication
Muscles
Musculoskeletal diseases
Musculoskeletal system
Myalgia
Pain
PAX7 Transcription Factor - genetics
Polymorphism genetic
Polymorphism, Single Nucleotide
Risk factors
Saliva
Single-nucleotide polymorphism
Statistical analysis
Stem Cells
Temporomandibular joint
Temporomandibular joint disorders
Temporomandibular Joint Disorders - diagnosis
Temporomandibular Joint Disorders - epidemiology
Temporomandibular Joint Disorders - genetics
Temporomandibular joint dysfunction syndrome
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlp15CmjSJ26SoUNpDMfFD1uO4KQkhkNJDA3sTkizRLbt2qL2E_PvMyN5lTQ695OCLHkaeh2ZGnvlEyJdCWedq5lKIlnnKbHCpAbanjoOvL41RLN4NePeT39yz23k137nqC3PCBnjggXAXBffCKlfaYCrmlbK5tIxbFkKOuNJ13H2zYhNMjf8PBNj9TYmM5Bcd7MKY4VPAw8Dipo8TMxTR-l_uyTtGaZowuWOBrg_I_ug60tmw5HfkjW8OydGsgbB59US_0pjMGU_Jj8jfX7O5oCAcnj60S4jvgZyLbkUXDV2th9xTOqBStSssbLGxpR6hODtqOpjXYyaRWS6faKx48TXt2zh96SniP1M89e_ek_vrq98_btLxWoXUVbzsU6kCBEGKMSaKzGdKZiZ4_MGZeSsx-QxIDF5aJiwoeFGVLpPCg6NmnPBK5qI8JntN2_hTQmVW1pWTzOLRcq6srIMHruQuhJKZPCTk-4bK-mFAz9Ax6pBcDzzRwBMdeaIfE3KJjNiOROTr2ADyoEd50P-Th4R8QzZq1E_glTNjmQEsGJGu9IxLjvW4kiXkbDIS9MpNuzeCoEe97jQEixIcSoiyEvJ5240zMVet8e06jlHgiFUcXnEyyM32k0omYH6eJ0RMJGryzdOeZvEnon5LvEmg4h9eg0gfydsClQHTGcUZ2ev_rf05OFe9_RT16BkA8SRo
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1Ni9QwNOjsxYuo60d1lQiiBynbjzRNTjIruyyCyyIuzC0kaaIjM-247bDsv_e9NDNuETz00iQl6ft-eR-EvCuksbZhNgVrmafMeJtqAHtqOej6QmvJQm_Arxf8_Ip9WVSL6HDrY1jljicGRt10Fn3kx6CmCxDloN9-2vxOsWsU3q7GFhr3yUGRl0LMyMHJ6cXlt_09Qg3yf5cqI_hxD9wYI30KeBhI3vRmIo5C1f5_efMd4TQNnLwjic4ekYdRhaTzEeaPyT3XPiGH8xbM5_UtfU9DUGfwlh-SX5fzRU0BSRzddCuw8-G3Lvs1XbZ0vR1jUOlYnapbY4KLCW-aWJKzp7qHdQNGFOnV6paGzBfX0KELy1eOYh1oit7__im5Ojv9_vk8je0VUlvxckiF9GAMScZYXWQukyLT3uFFZ-aMwCA0A9KfAw8wQOhFVdpM1A4UNm1rJ0Vel8_IrO1a94JQkZVNZQUz6GLOpRGNd1K73HpfMp37hHzc_WW1GatoqGB9CK5GmCiAiQowUTcJOUFA7GdiBezworv-oSJBqYK72khbGq8r5qSEzRrGDfM-x3rjTUI-IBgV0inAyuqYbgAbxopXas4Fx7xcwRJyNJkJ9GWnwztEUJG-e_UXGxPydj-MKzFmrXXdNsyRoJBVHD7xfMSb_ZFKVsP6PE9IPcGoyZmnI-3yZ6j-LbCjQMVf_n9br8iDAtEcAxbrIzIbrrfuNahPg3kTaeQP-2QcIg
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKuXBBQHmEFmQkBAcUyMPx44DQgqgqpCIOrLQ3y3YcWLSbtJusyv57ZpxkaUQvHHKJ7SjxvOOZbwh5mSnrXMlcDNEyj5mtXGyA7LHj4OtLYxQLvQHPv_KzOfuyKBYHZGx3NGxge2Noh_2k5pvV29-Xuw8g8O-DwEv-rgUdi_k7GVwM7Gl8dYvczsAyYorXOft7qiBk6CyWgkKOMybYWERz4zMmhirg-f-rta-ZrWlK5TUbdXqP3B2cSzrrueE-OfD1A3I0qyGwXu_oKxrSPcN_9CPy69tsISiwj6cXzWq3bmDDl-2aLmu63vbZqbTHrWrWWPpiw51yAOtsqWlhXYe5Rma12tFQE-NL2jVh-cpTRIimeC7QPiTz08_fP53FQ-OF2BU872KpKgiTFGNMZIlPlExM5fEINPFWYnqaBb-Ag3awoAKyIneJFB5cOeOEVzIV-SNyWDe1f0KoTPKycJJZ_PmcKivLyivjU1dVOTNpFZE34y7rix5fQ4e4RHLd00QDTXSgib6KyEckxH4mYmOHG83mhx5ETWfcC6tcbitTMK8UvKxl3LKqShGJvIzIaySjRp4CWjkzFCLACyMWlp5xybFiV7KInExmguS56fDICHpkXA3hpASXE-KwiLzYD-NKzGarfbMNcxS4agWHRzzu-Wb_STkTsD5NIyImHDX55ulIvfwZcMEl9hoo-NP_2tJjcidDrsfMRnFCDrvN1j8DP6uzz4Pw_AGR-SP1
  priority: 102
  providerName: Scholars Portal
Title PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
URI https://www.ncbi.nlm.nih.gov/pubmed/34789211
https://www.proquest.com/docview/2598929675
https://search.proquest.com/docview/2599075564
https://pubmed.ncbi.nlm.nih.gov/PMC8600756
https://doaj.org/article/26e7b9c3bfa54e99b18b46b4ff19ae9d
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZJCiWX0jZ9uE0XFUp7KM76IetxdEJCWNiwtA3sTUiynG5Z20u8S8i_70i2l5jeerANehjZM6PRyN98RuhLIrQxBTEhRMs0JLo0oQKxh4bCWp8rJYj_N-D8hl7fktkyWx6gbMiF8aB9o1dn9bo6q1e_PbZyU5npgBObLuYX3JGqZ3R6iA7B_Q4hev_pgIHLH7JjOJ22MAE7cE8CBwFnGz4co-cpYVwkcTxyRp6z_9-Z-YlrGsMmn_ihq5foRb-AxHk30FfowNav0UleQ_BcPeKv2EM6_V75CfqzyJcMg4pYvGnWEOXDS121FV7VuNp1CFTccVM1lUtv0b6k6Ak5W6xa6Ld1eCK1Xj9in_diC7xtfPe1xY4FGru9__YNur26_HVxHfY_VwhNRtNtyEUJoZAghLAkspHgkSqt-8wZWc0dBE2D76cwA2gw8yRLTcSZheWaMswKHrP0LTqqm9q-R5hHaZEZTrTbYI6F5kVphbKxKcuUqLgM0PfhLctNx6EhfezBqezEI0E80otHPgTo3Ali39LxX_uC5v5O9logE2qZFibVpcqIFQIGqwnVpCxjxzZeBOibE6N0VgqyMqpPNoABO74rmVNOXVYuJwE6HbUE6zLj6kERZG_drYSQEdRHQKwVoM_7atfTIdZq2-x8GwFKmlG4xbtOb_aPNKhfgNhIo0bPPK4BU_Dc373qf_jvnh_RceKMwSEZ2Sk62t7v7CdYV231BKxpySboWZ7Pfs7gen55s_gx8bsUcJ4TPvGW9hdG2ilp
link.rule.ids 230,314,727,780,784,864,885,2102,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELege4AXBIyPwAAjIXhA0fLh-OMJdWhTga2a0Cb1zbIdB4rapCytpv333DlpWYTEQ19iu3Jyd74P3_2OkHeZss6VzMXgLfOY2crFBsgeOw62vjRGsdAb8GzKJ5fs66yY9QG3tk-r3J6J4aAuG4cx8kMw0yWocrBvP61-x9g1Cm9X-xYad8keIqcXI7J3dDw9_767RxCg_7elMpIftnAaY6ZPBj8Gmje-HqijgNr_79l8SzkNEydvaaKTh-RBb0LScUfzR-SOrx-T_XEN7vPyhr6nIakzRMv3ya_z8UxQYBJPV80C_Hz4rPN2Sec1XW66HFTaoVM1SyxwseFJ2UNyttS0sG6NGUVmsbihofLFl3TdhOULTxEHmmL0v31CLk-OLz5P4r69QuwKnq9jqSpwhhRjTGSJT5RMTOXxojPxVmISmgXtz-EMsCDoWZG7RAoPBptxwiuZivwpGdVN7Z8TKpO8LJxkFkPMqbKyrLwyPnVVlTOTVhH5uP3KetWhaOjgfUiuO5pooIkONNHXETlCQuxmIgJ2eNBc_dC9QOmMe2GVy21lCuaVgs1axi2rqhTxxsuIfEAyapRToJUzfbkBbBgRr_SYS451uZJF5GAwE-TLDYe3jKB7-W71X26MyNvdMK7EnLXaN5swR4FBVnD4i2cd3-xeKWcC1qdpRMSAowbvPByp5z8D-rfEjgIFf_H_bb0h9yYXZ6f69Mv020tyP0OWx-RFcUBG66uNfwWm1Nq-7uXlD2YOHwo
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagSFUvCCiPQAEjITigNC_HsY9LYVUerfZApb1ZtmOXRZtk1WRV9d8zdpLVRtw45BLbkZOZ8czE33xG6H3KldYl0SFkyzQkyupQgthDTSHWZ1Jy4s8GvLik51fk-zJf7h315UH7Wq1O63V1Wq9-e2zlptLRiBOLFhdnzJGq5zTalDa6jx7kGSjZmKgPGwgFOP6xRobRqIVl2EF8UrgIuNzw9ggdZqRgPE2SiUvyzP3_rs97DmoKntzzRvNH6OEQRuJZP93H6J6pn6DjWQ0pdHWHP2AP7PR_zI_Rn8VsWWBQFIM3zRpyffi0q7bCqxpX2x6HinuGqqZyRS7K3ykHWs4WyxbGdQ5VJNfrO-yrX0yJu8YPXxvsuKCx2wFon6Kr-ddfZ-fhcMRCqHOadSHjFhIiTggp0tjEnMXSGrfZGRvFHBBNQQRAYR1QYOxpnumYFQaCNqkLw1lSZM_QQd3U5gXCLM7KXDOi3G_mhCtWWsOlSbS1GZGJDdCn8SuLTc-kIXwGwqjoxSNAPMKLR9wG6LMTxK6nY8H2N5qbazHogkipKRTXmbIyJ4ZzmKwiVBFrE8c5XgbooxOjcLYKstJyKDmACTvWKzGjjLraXEYCdDLpCTamp82jIojBxlsBiSOoD4eMK0Dvds1upMOt1abZ-j4cVDWn8Ijnvd7sXmlUvwAVE42avPO0BQzCM4APBvDyv0e-RYeLL3Px89vlj1foKHV24aCNxQk66G625jUEWp16403qL8hmJ_U
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=PAX7+gene+polymorphism+in+muscular+temporomandibular+disorders+as+potentially+related+to+muscle+stem+cells&rft.jtitle=BMC+musculoskeletal+disorders&rft.au=Quinelato%2C+Valquiria&rft.au=Bonato%2C+Let%C3%ADcia+Ladeira&rft.au=Vieira%2C+Alexandre+Rezende&rft.au=Granjeiro%2C+Jos%C3%A9+Mauro&rft.date=2021-11-17&rft.issn=1471-2474&rft.eissn=1471-2474&rft.volume=22&rft.issue=1&rft_id=info:doi/10.1186%2Fs12891-021-04846-w&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s12891_021_04846_w
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2474&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2474&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2474&client=summon